Alternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systems

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dc.citation.issue4
dc.citation.volume18
dc.contributor.authorJunqueira Garcia, Maria Teresa [UNIFESP]
dc.contributor.authorLopes de Vasconcellos, Fabia Leal [UNIFESP]
dc.contributor.authorRaffier, Chloe Patricia
dc.contributor.authorRoberts, Michael Stephen
dc.contributor.authorGrice, Jeffrey Ernest
dc.contributor.authorElizabeth Benson, Heather Ann
dc.contributor.authorLeite-Silva, Vania Rodrigues [UNIFESP]
dc.coverageSharjah
dc.date.accessioned2020-07-08T13:09:54Z
dc.date.available2020-07-08T13:09:54Z
dc.date.issued2018
dc.description.abstractIt is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/ permeation studies.en
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.affiliationUniv Queensland, Diamantina Inst, Translat Res Inst, Therapeut Res Ctr, Brisbane, Qld, Australia
dc.description.affiliationUniv South Australia, Sch Pharm & Med Sci, Adelaide, SA, Australia
dc.description.affiliationCurtin Univ Technol, Curtin Hlth Innovat Res Inst, Sch Pharm & Biomed Sci, Perth, WA, Australia
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent287-299
dc.identifierhttp://dx.doi.org/10.2174/1568026618666180412153214
dc.identifier.citationCurrent Topics In Medicinal Chemistry. Sharjah, v. 18, n. 4, p. 287-299, 2018.
dc.identifier.doi10.2174/1568026618666180412153214
dc.identifier.issn1568-0266
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54282
dc.identifier.wosWOS:000433386800005
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Topics In Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSkin penetrationen
dc.subjectDrug delivery systemsen
dc.subjectAlternative methodsen
dc.subjectIn vivoen
dc.subjectEx vivoen
dc.subjectIn silicoen
dc.subjectSkin permeationen
dc.titleAlternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systemsen
dc.typeinfo:eu-repo/semantics/article
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