Increased vascular sympathetic modulation in mice with Mas receptor deficiency

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dc.citation.issue2
dc.citation.volume17
dc.contributor.authorCasali, Karina Rabello [UNIFESP]
dc.contributor.authorDartora, Daniela Ravizzoni
dc.contributor.authorMoura, Marina
dc.contributor.authorBertagnolli, Mariane
dc.contributor.authorBader, Michael [UNIFESP]
dc.contributor.authorHaibara, Andrea
dc.contributor.authorAlenina, Natalia
dc.contributor.authorIrigoyen, Maria Claudia [UNIFESP]
dc.contributor.authorSantos, Robson A.
dc.coverageLondon
dc.date.accessioned2020-07-22T13:23:11Z
dc.date.available2020-07-22T13:23:11Z
dc.date.issued2016
dc.description.abstractIntroduction: The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk and provide information about the autonomic modulation of the cardiovascular system. Therefore we investigated the effect of Mas deficiency on autonomic modulation in wild type and Mas-knockout (KO) mice. Methods: Blood pressure was recorded at high sample rate (4000 Hz). Stationary sequences of 200-250 beats were randomly chosen. Frequency domain analysis of HR and BPV was performed with an autoregressive algorithm on the pulse interval sequences and on respective systolic sequences. Results: The KO group presented an increase of systolic arterial pressure (SAPen
dc.description.abstract127.26 +/- 11.20 vs 135.07 +/- 6.98 mmHg), BPV (3.54 +/- 1.54 vs 5.87 +/- 2.12 mmHg(2)), and low-frequency component of systolic BPV (0.12 +/- 0.11 vs 0.47 +/- 0.34 mmHg(2)). Conclusions: The deletion of Mas receptor is associated with an increase of SAP and with an increased BPV, indicating alterations in autonomic control. Increase of sympathetic vascular modulation in absence of Mas evidences the important role of Ang-(1-7)/Mas on cardiovascular regulation. Moreover, the absence of significant changes in HR and HRV can indicate an adaptation of autonomic cardiac balance. Our results suggest that the Ang-(1-7)/Mas axis seems more important in autonomic modulation of arterial pressure than HR.en
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Cardiol, Inst Cardiol Fundacao, Princesa Isabel 370, Porto Alegre, RS, Brazil
dc.description.affiliationMax Delbruck Ctr Mol Med, Berlin, Germany
dc.description.affiliationCHU Sainte Justine Res, Montreal, PQ, Canada
dc.description.affiliationInst Coracao InCor, Sao Paulo, Brazil
dc.description.affiliationNatl Inst Sci & Technol Nanobiopharmaceut, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Science and Technology in Nanobiopharmaceutics
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (Cnpq)
dc.description.sponsorshipPrograma Nacional de Pos Doutorado (PNPD-CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1177/1470320316643643
dc.identifier.citationJournal Of The Renin-Angiotensin-Aldosterone System. London, v. 17, n. 2, p. -, 2016.
dc.identifier.doi10.1177/1470320316643643
dc.identifier.fileWOS000378273800001.pdf
dc.identifier.issn1470-3203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56085
dc.identifier.wosWOS:000378273800001
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal Of The Renin-Angiotensin-Aldosterone System
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenin-angiotensin systemen
dc.subjectangiotensin-(1-7)en
dc.subjectMas receptoren
dc.subjectautonomic modulationen
dc.subjectblood pressure variabilityen
dc.subjectheart rate variabilityen
dc.titleIncreased vascular sympathetic modulation in mice with Mas receptor deficiencyen
dc.typeinfo:eu-repo/semantics/article
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