Kidney-Derived c-Kit(+) Cells Possess Regenerative Potential

dc.citation.issue4
dc.citation.volumev. 7
dc.contributor.authorGomes, Samirah A.
dc.contributor.authorHare, Joshua M.
dc.contributor.authorRangel, Erika Bevilaqua [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-20T16:31:09Z
dc.date.available2020-07-20T16:31:09Z
dc.date.issued2018
dc.description.abstractKidney-derived c-Kit(+) cells exhibit progenitor/stem cell properties in vitro (self-renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia-reperfusion injury and accelerate foot processes effacement reversal in a model of acute proteinuria in rats. Several mechanisms are involved in kidney regeneration by kidney-derived c-Kit(+ )cells, including cell engraftment and differentiation into renal-like structures, such as tubules, vessels, and podocytes. Moreover, paracrine mechanisms could also account for kidney regeneration, either by stimulating proliferation of surviving cells or modulating autophagy and podocyte cytoskeleton rearrangement through mTOR-Raptor and -Rictor signaling, which ultimately lead to morphological and functional improvement. To gain insights into the functional properties of c-Kit(+) cells during kidney development, homeostasis, and disease, studies on lineage tracing using transgenic mice will unveil their fate. The results obtained from these studies will set the basis for establishing further investigation on the therapeutic potential of c-Kit(+) cells for treatment of kidney disease in preclinical and clinical studies.en
dc.description.affiliationUniv Sao Paulo, Renal Div, Lab Cellular Genet & Mol Nephrol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Miami, Leonard M Miller Sch Med, Interdisciplinary Stem Cell Inst, Miami, FL USA
dc.description.affiliationUniv Miami, Leonard M Miller Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL USA
dc.description.affiliationUniv Miami, Div Cardiol, Leonard M Miller Sch Med, Miami, FL USA
dc.description.affiliationHosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, Albert Einstein Ave,627-701 Bldg A, BR-05652900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional em Pesquisa e Desenvolvimento (CNPq)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipEuropean Foundation for the Study of Diabetes (EFSD)
dc.description.sponsorshipIDCNPq: 456959/2013-0
dc.description.sponsorshipIDFAPESP: 13/19560-6
dc.format.extent317-324
dc.identifierhttp://dx.doi.org/10.1002/sctm.17-0232
dc.identifier.citationStem Cells Translational Medicine. Hoboken, v. 7, n. 4, p. 317-324, 2018.
dc.identifier.doi10.1002/sctm.17-0232
dc.identifier.fileWOS000428344500001.pdf
dc.identifier.issn2157-6564
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55748
dc.identifier.wosWOS:000428344500001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofStem Cells Translational Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleKidney-Derived c-Kit(+) Cells Possess Regenerative Potentialen
dc.typeinfo:eu-repo/semantics/article
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