Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

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dc.contributor.authorCramarossa, Gemma
dc.contributor.authorZeng, Liang
dc.contributor.authorZhang, Liying
dc.contributor.authorTseng, Ling-Ming
dc.contributor.authorHou, Ming-Feng
dc.contributor.authorFairchild, Alysa
dc.contributor.authorVassiliou, Vassilios
dc.contributor.authorJesus-Garcia, Reynaldo [UNIFESP]
dc.contributor.authorEl-Din, Mohamed A. Alm
dc.contributor.authorKumar, Aswin
dc.contributor.authorForges, Fabien
dc.contributor.authorChie, Wei-Chu
dc.contributor.authorSahgal, Arjun
dc.contributor.authorLam, Henry
dc.contributor.authorPulenzas, Natalie
dc.contributor.authorChow, Edward
dc.contributor.institutionUniv Toronto
dc.contributor.institutionNatl Yang Ming Univ
dc.contributor.institutionKaohsiung Med Univ Hosp
dc.contributor.institutionCross Canc Inst
dc.contributor.institutionBank Cyprus
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTanta Univ Hosp
dc.contributor.institutionReg Canc Ctr
dc.contributor.institutionSt Etienne Univ Hosp
dc.contributor.institutionNatl Taiwan Univ
dc.date.accessioned2016-01-24T14:35:17Z
dc.date.available2016-01-24T14:35:17Z
dc.date.issued2014-02-01
dc.description.abstractObjective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients. Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30). Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. in the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. in patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL. Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.en
dc.description.affiliationUniv Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada
dc.description.affiliationNatl Yang Ming Univ, Taipei Vet Gen Hosp, Dept Surg, Taipei 112, Taiwan
dc.description.affiliationKaohsiung Med Univ Hosp, Dept Surg Gastroenterol, Kaohsiung, Taiwan
dc.description.affiliationCross Canc Inst, Dept Radiat Oncol, Edmonton, AB T6G 1Z2, Canada
dc.description.affiliationBank Cyprus, Dept Radiat Oncol, Ctr Oncol, Nicosia, Cyprus
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped Oncol, São Paulo, Brazil
dc.description.affiliationTanta Univ Hosp, Tanta Fac Med, Dept Clin Oncol, Tanta, Egypt
dc.description.affiliationReg Canc Ctr, Div Gynaecol & Genitourinary Oncol, Dept Radiat Oncol, Trivandrum 695011, Kerala, India
dc.description.affiliationSt Etienne Univ Hosp, INSERM, CIE3, St Etienne, France
dc.description.affiliationSt Etienne Univ Hosp, Unit Clin Res Innovat & Pharmacol, St Etienne, France
dc.description.affiliationNatl Taiwan Univ, Dept Publ Hlth, Taipei 10764, Taiwan
dc.description.affiliationNatl Taiwan Univ, Inst Epidemiol & Preventat Med, Taipei 10764, Taiwan
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped Oncol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBratty Family Fund
dc.description.sponsorshipMichael and Karyn Goldstein Cancer Research Fund
dc.description.sponsorshipJoseph and Silvana Melara Cancer Research Fund
dc.description.sponsorshipOfelia Cancer Research Fund
dc.format.extent139-146
dc.identifierhttp://dx.doi.org/10.1586/14737167.2014.864560
dc.identifier.citationExpert Review of Pharmacoeconomics & Outcomes Research. London: Expert Reviews, v. 14, n. 1, p. 139-146, 2014.
dc.identifier.doi10.1586/14737167.2014.864560
dc.identifier.issn1473-7167
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37420
dc.identifier.wosWOS:000336258600015
dc.language.isoeng
dc.publisherExpert Reviews
dc.relation.ispartofExpert Review of Pharmacoeconomics & Outcomes Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectadvanced canceren
dc.subjectEORTC QLQ-C30en
dc.subjectmetastatic canceren
dc.subjectquality of lifeen
dc.subjectsymptom controlen
dc.titlePredictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30en
dc.typeinfo:eu-repo/semantics/article
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