Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

Página do item simplificado
dc.contributor.authorPedrazzoli, M.
dc.contributor.authorD'Almeida, V
dc.contributor.authorMartins, PJF
dc.contributor.authorMachado, R. B.
dc.contributor.authorLing, L.
dc.contributor.authorNishino, S.
dc.contributor.authorTufik, S.
dc.contributor.authorMignot, E.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionStanford Univ
dc.date.accessioned2016-01-24T12:34:14Z
dc.date.available2016-01-24T12:34:14Z
dc.date.issued2004-01-02
dc.description.abstractRat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 It of REM sleep deprivation and following 24 It of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 It of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity. (C) 2003 Elsevier B.V All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Sleep Inst, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationStanford Univ, Ctr Narcolepsy, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sleep Inst, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1-6
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2003.09.032
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 995, n. 1, p. 1-6, 2004.
dc.identifier.doi10.1016/j.brainres.2003.09.032
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27581
dc.identifier.wosWOS:000187747400001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecthypocretin-1en
dc.subjectcerebrospinal fluiden
dc.subjectREM sleepen
dc.titleIncreased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivationen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral