Renal transplantation in human immunodeficiency virus-infected recipients: a case-control study from the Brazilian experience

Página do item simplificado
dc.citation.issue5
dc.citation.volume18
dc.contributor.authorVicari, A. R.
dc.contributor.authorSpuldaro, F.
dc.contributor.authorFreitas, Tainá Veras de Sandes [UNIFESP]
dc.contributor.authorCristelli, Marina Pontello [UNIFESP]
dc.contributor.authorRequiao-Moura, L. R.
dc.contributor.authorReusing, J. O.
dc.contributor.authorPierrotti, L. C.
dc.contributor.authorOliveira, M. L.
dc.contributor.authorGirao, C. M.
dc.contributor.authorGadonski, G.
dc.contributor.authorKroth, L. V.
dc.contributor.authorDeboni, L. M.
dc.contributor.authorFerreira, G. F.
dc.contributor.authorTedesco-Silva, Helio [UNIFESP]
dc.contributor.authorEsmeraldo, R.
dc.contributor.authorDavid-Neto, E.
dc.contributor.authorSaitovitch, D.
dc.contributor.authorKeitel, E.
dc.contributor.authorGarcia, V. D.
dc.contributor.authorPacheco-Silva, A.
dc.contributor.authorPestana, Jose Osmar Medina [UNIFESP]
dc.contributor.authorManfro, R. C.
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractBackgroundHighly active antiretroviral therapy has turned human immunodeficiency virus (HIV)-infected patients with end-stage renal disease into suitable candidates for renal transplantation. We present the Brazilian experience with kidney transplantation in HIV-infected recipients observed in a multicenter study. MethodsHIV-infected kidney transplant recipients and matched controls were evaluated for the incidence of delayed graft function (DGF), acute rejection (AR), infections, graft function, and survival of patients and renal grafts. ResultsFifty-three HIV-infected recipients and 106 controls were enrolled. Baseline characteristics were similar, but a higher frequency of pre-transplant positivity for hepatitis C virus and cytomegalovirus infections was found in the HIV group. Immunosuppressive regimens did not differ, but a trend was observed toward lower use of anti-thymocyte globulin in the group of HIV-infected recipients (P = 0.079). The HIV-positive recipient group presented a higher incidence of treated AR (P = 0.036) and DGF (P = 0.044). Chronic Kidney Disease Epidemiology Collaboration estimated that glomerular filtration rate was similar at 6 months (P = 0.374) and at 12 months (P = 0.957). The median number of infections per patient was higher in the HIV-infected group (P = 0.018). The 1-year patient survival (P < 0.001) and graft survival (P = 0.004) were lower, but acceptable, in the group of HIV-infected patients. ConclusionsIn the Brazilian experience, despite somewhat inferior outcomes, kidney transplantation is an adequate therapy for selected HIV-infected recipients.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Renal Transplant Unit, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Hosp Rim, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Renal Transplant Unit, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Hosp Clin Sao Paulo, Renal Transplant Unit, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Geral Fortaleza, Renal Transplant Unit, Fortaleza, Ceara, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Renal Transplant Unit, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Municipal Sao Jose & Fundacao Pro Rim, Joinville, SC, Brazil
dc.description.affiliationHosp Santa Casa Misericordia Juiz de Fora, Juiz De Fora, MG, Brazil
dc.description.affiliationFed Univ Med Sci Porto Alegre, Hosp Santa Casa Porto Alegre, Renal Transplant Unit, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespHospital do Rim, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent730-740
dc.identifierhttp://dx.doi.org/10.1111/tid.12592
dc.identifier.citationTransplant Infectious Disease. Hoboken, v. 18, n. 5, p. 730-740, 2016.
dc.identifier.doi10.1111/tid.12592
dc.identifier.issn1398-2273
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57003
dc.identifier.wosWOS:000385705300011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofTransplant Infectious Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectkidney transplantationen
dc.subjecthuman immunodeficiency virusen
dc.subjectgraft survivalen
dc.subjectsurvival analysisen
dc.subjectgraft rejectionen
dc.titleRenal transplantation in human immunodeficiency virus-infected recipients: a case-control study from the Brazilian experienceen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos