Distribution of tonin- and kallikrein-like activities in rat brain

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dc.contributor.authorLopes, E. S.
dc.contributor.authorSumitani, M.
dc.contributor.authorJuliano, L.
dc.contributor.authorBeraldo, W. T.
dc.contributor.authorPesquero, J. L.
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:27Z
dc.date.available2016-01-24T12:30:27Z
dc.date.issued1997-09-19
dc.description.abstractTonin- and kallikrein-like activities were investigated in different regions of the rat brain. the highest values of specific tonin activity, expressed as picomoles of angiotensin II liberated per minute per milligram of protein, were found in the neurohypophysis (359 +/- 190) and in the archicerebellum (200 +/- 68). the highest level of total tonin activity (picomoles of angiotensin IT liberated per minute) was observed in the archicerebellum (902 +/- 308) which retained 97% of total tonin activity of whole cerebellum. Tonin activity was not detected in the cortex of cerebellum and in the choroid plexus. Low to intermediate values of specific (1.09 +/- 0.33 to 5.32 +/- 2.37) and total (1.38 +/- 0.55 to 93.00 +/- 49.30) tonin activity were observed in adenohypophysis, cerebellar nuclei, hypothalamus, thalamus, midbrain, pens, medulla and neurohypophysis. the lowest values of specific (0.11 +/- 0.05) and total (0.69 +/- 0.31) activities were observed in the hippocampus. Kallikrein-like activity was expressed as picomoles of p-nitroaniline liberated per minute per milligram of protein. No activity was detected in the neurohypophysis. for other regions, the values of the specific activity ranged between 72 +/- 18 and 282 +/- 14 except for the choroid plexus which was 5 +/- 2. the total kallikrein activity was also homogeneous ranging from 330 +/- 100 to 1870 +/- 112. for the choroid plexus and adenohypophysis the total kallikrein activity was 2.0 +/- 0.8 and 27 +/- 11, respectively. (C) 1997 Elsevier Science B.V.en
dc.description.affiliationUNIV FED MINAS GERAIS,INST CIENCIAS BIOL,DEPT PHYSIOL & BIOPHYS,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationUniversidade Federal de São Paulo,DEPT BIOPHYS,São Paulo,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,DEPT BIOPHYS,São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent152-157
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(97)00785-3
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 769, n. 1, p. 152-157, 1997.
dc.identifier.doi10.1016/S0006-8993(97)00785-3
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25787
dc.identifier.wosWOS:A1997YB98700017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecttoninen
dc.subjectkallikreinen
dc.subjectangiotensinaseen
dc.subjectangiotensin IIen
dc.subjectrat brainen
dc.titleDistribution of tonin- and kallikrein-like activities in rat brainen
dc.typeinfo:eu-repo/semantics/article
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