DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts

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dc.citation.issue1
dc.citation.volume131
dc.contributor.authorIto da Cruz, Luiz Guilherme [UNIFESP]
dc.contributor.authorMoraes, Gabriela de Andrade
dc.contributor.authorNogueira, Regina Freitas [UNIFESP]
dc.contributor.authorMorandim-Giannetti, Andreia de Araujo
dc.contributor.authorBersanetti, Patricia Alessandra [UNIFESP]
dc.coverageDordrecht
dc.date.accessioned2020-07-02T18:52:08Z
dc.date.available2020-07-02T18:52:08Z
dc.date.issued2018
dc.description.abstractKeratoconus is an eye ectasia that affects the cornea causing distortion of vision. Corneal crosslinking promoted by riboflavin photo-stimulated at 365 nm is a treatment used successfully to block the keratoconus progression. In this study, we characterize rabbit corneas subjected to enhanced crosslinking using different vegetable extracts prepared from Stryphnodendron adstringens (Mart.) Coville bark by differential scanning calorimetry. The extracts tested in this study were: aqueous, ketonic, ethanolic, ethyl acetate and hydroalcoholic, which revealed high levels of polyphenols, such as proanthocyanidins. The corneas, obtained from the slaughter rabbits, were divided into groups: control (consisting of untreated corneal samples) and S. adstringens, where the samples were subjected to 4% vegetable extracts for 2 h. The DSC profiles of the corneas were obtained in nitrogen atmosphere. The results showed that temperature and enthalpy of denaturation of the corneal samples treated with S. adstringens were higher than the control group. The control group presents temperature and enthalpy values of 59.8 +/- 1.1 A degrees C and 24.6 +/- 2.7 J g(-1), respectively. After crosslinking with ketone extract, the values were 90.1 +/- 1.1 A degrees C and 39.9 +/- 2.7 J g(-1). These results show that S. adstringens is efficient to increment the crosslinking level of the corneas.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Oftalmol & Ciencias Visuais, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Informat Saude, Sao Paulo, SP, Brazil
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, Sao Bernardo Do Campo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Oftalmol & Ciencias Visuais, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Informat Saude, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2013/20857-3]
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDFAPESP [2013/20857-3]
dc.format.extent621-625
dc.identifierhttp://dx.doi.org/10.1007/s10973-017-6096-8
dc.identifier.citationJournal Of Thermal Analysis And Calorimetry. Dordrecht, v. 131, n. 1, p. 621-625, 2018.
dc.identifier.doi10.1007/s10973-017-6096-8
dc.identifier.fileWOS000419786700068.pdf
dc.identifier.issn1388-6150
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53900
dc.identifier.wosWOS:000419786700068
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Thermal Analysis And Calorimetry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorneaen
dc.subjectCrosslinkingen
dc.subjectPolyphenolsen
dc.subjectStryphnodendron adstringensen
dc.titleDSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extractsen
dc.typeinfo:eu-repo/semantics/article
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