Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.

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dc.citation.volumev. 56
dc.contributor.authorLopes-Bezerra, Leila Maria
dc.contributor.authorMora-Montes, Hector M.
dc.contributor.authorZhang, Yu
dc.contributor.authorNino-Vega, Gustavo
dc.contributor.authorRodrigues, Anderson Messias [UNIFESP]
dc.contributor.authorCamargo, Zoilo Pires [UNIFESP]
dc.contributor.authorHoog, Sybren
dc.coverageOxford
dc.date.accessioned2020-07-20T16:31:12Z
dc.date.available2020-07-20T16:31:12Z
dc.date.issued2018
dc.description.abstractThe description of cryptic species with different pathogenic potentials has changed the perspectives on sporotrichosis. Sporothrix schenckii causes a benign chronic subcutaneous mycosis, Sporothrix brasiliensis is highly virulent, and Sporothrix globosa mainly causes fixed cutaneous lesions. Furthermore, S. brasiliensis is the prevalent species related to cat-transmitted sporotrichosis. Sources of infection, transmission, and distribution patterns also differ between species, and variability differs between species because of different degrees of clonality. The present review article will cover several aspects of the biology of clinically relevant agents of sporotrichosis, including epidemiological aspects of emerging species. Genomic information of Sporothrix spp. is also discussed. The cell wall is an essential structure for cell viability, interaction with the environment, and the host immune cells and contains several macromolecules involved in virulence. Due to its importance, aspects of glycosylation and cell wall polysaccharides are reviewed. Recent genome data and bioinformatics analyses helped to identify specific enzymes of the biosynthetic glycosylation routes, with no homologs in mammalian cells, which can be putative targets for development of antifungal drugs. A diversity of molecular techniques is available for the recognition of the clinically relevant species of Sporothrix. Furthermore, antigens identified as diagnostic markers and putative vaccine candidates are described. Cell-mediated immunity plays a key role in controlling infection, but Sporothrix species differ in their interaction with the host. The adaptive branch of the immune response is essential for appropriate control of infection.en
dc.description.affiliationUniv Estado Rio De Janeiro, Dept Cell Biol, Lab Cellular Mycol & Prote, Sao Francisco Xavier St 524 PHLC 501D, BR-20550013 Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Guanajuato, Dept Biol, Div Ciencias Nat & Exactas, Campus Guanajuato, Guanajuato, Mexico
dc.description.affiliationTianjin Acad Tradit Chinese Med, Dept Dermatol, Affiliated Hosp, Tianjin, Peoples R China
dc.description.affiliationUniv Fed Sao Paulo, Cell Biol Div, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationWesterdijk Fungal Biodivers Inst, Utrecht, Netherlands
dc.description.affiliationRadboudumc CWZ, Ctr Expertise Mycol, Nijmegen, Netherlands
dc.description.affiliationUnifespUniv Fed Sao Paulo, Cell Biol Div, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologia
dc.description.sponsorshipUniversidad de Guanajuato
dc.description.sponsorshipUniversidad de Guanajuato (Convocatoria Institucional para Fortalecer la Excelencia Academica)
dc.description.sponsorshipPrograma de Mejoramiento de Profesorado
dc.description.sponsorshipRed Tematica Glicociencia en Salud (CONACYT-Mexico)
dc.description.sponsorshipTianjin Municipal Natural Science Foundation
dc.description.sponsorshipIDCNPq: 307169/2015-4
dc.description.sponsorshipIDCNCT: CB2011/166860
dc.description.sponsorshipIDCNCT: PDCPN2014-247109
dc.description.sponsorshipIDCNCT: FC 2015-02-834
dc.description.sponsorshipIDUG: 0087/13
dc.description.sponsorshipIDUG: 1025/2016
dc.description.sponsorshipIDCIFOREA: 89/2016
dc.description.sponsorshipIDPMP: UGTO-PTC-261
dc.description.sponsorshipIDTMNSC: 15JCYBJC49500
dc.format.extentS126-S143
dc.identifierhttp://dx.doi.org/10.1093/mmy/myx103
dc.identifier.citationMedical Mycology. Oxford, v. 56, Suppl. 1, p. S126-S143, 2018.
dc.identifier.doi10.1093/mmy/myx103
dc.identifier.issn1369-3786
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55786
dc.identifier.wosWOS:000427254400012
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofMedical Mycology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSporothrix schenckiien
dc.subjectSporothrix brasiliensisen
dc.subjectSporothrix globosaen
dc.subjectgenomeen
dc.subjectsporotrichosisen
dc.titleSporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.en
dc.typeinfo:eu-repo/semantics/review
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