Ethanol intake during lactation I. Effects on dams' metabolism and pups' body weight gain

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dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorCouto, Rosany Carvalho do
dc.contributor.authorCouto, Gilmar Eduardo Costa do
dc.contributor.authorDâmaso, Ana Raimunda
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Amazonas
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2016-01-24T12:31:07Z
dc.date.available2016-01-24T12:31:07Z
dc.date.issued2000-07-01
dc.description.abstractWistar lactating rats (8 pups per dam) had free access to either tap water (control group, C) or one of three concentrations of ethanol (E) in the drinking water: 5% (E5), 10% (E10), and 20% (E20). All animals received normal rat chow ad libitum and were killed on day 12 of lactation. Intake of both 10% and 20% ethanol solutions decreased food intake, dams' body weight, and pups' body weight gain as compared with findings in the C group. the relative weights (g/100g b.w.) of the mammary glands (MG) and of the parametrial white adipose tissue depot were decreased only in E20 as compared with findings in the C group, Protein and lipid content of these tissues were not altered in any of the ethanol groups. in comparison with the C group, the lipogenesis rate was increased in the MG (135.6%) and liver (120.2%) in E5 and the MG (58.1%) and parametrial white adipose tissue depot (147.0%) in E20. No modifications in lipogenesis rate were noted in E10. the malic enzyme activity was decreased in the MG in E10 (25.3%) and E20 (26.4%) and in the liver in E20 (45.7%). in E5, however, it was increased in the liver (23.9%). the activity of ATP - citrate lyase in the liver was decreased in E20 (56.7%), while it was increased by 37.5% in E5 and 34.2% in E10. Blood glucose concentration of dams was not affected by ethanol ingestion. However, plasma triacylglycerol concentration was higher in E10 (17.9%) and E20 (13.3%) than in the C group, and plasma protein was lower in E20 (15.7%) than in C. We concluded that alcohol intake during lactation increased the MG lipogenesis rate; although at the highest dose, this metabolic alteration was not enough to allow normal pups' growth. However, the low dose of ethanol (5%), despite having altered dams' metabolism, did not affect pups' body weight gain. 8 2000 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Fisiol, Disciplina Neurofisiol & Fisiol Endocrina, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniv Amazonas, Dept Ciencias Fisiol, BR-69007000 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Amazonas, Dept Desporto & Atividades Comunitarias, BR-69007000 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Educ Fis & Motricidade Humana, BR-13565535 Sao Carlos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Fisiol, Disciplina Neurofisiol & Fisiol Endocrina, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent195-200
dc.identifierhttps://dx.doi.org/10.1016/S0741-8329(00)00073-2
dc.identifier.citationAlcohol. Oxford: Pergamon-Elsevier B.V., v. 21, n. 3, p. 195-200, 2000.
dc.identifier.doi10.1016/S0741-8329(00)00073-2
dc.identifier.issn0741-8329
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26337
dc.identifier.wosWOS:000165348900001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAlcohol
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAlcoholen
dc.subjectLactationen
dc.subjectMammary glanden
dc.subjectLiveren
dc.subjectLipogenesisen
dc.subjectRaten
dc.subjectATP-citrate lyaseen
dc.subjectMalic enzymeen
dc.titleEthanol intake during lactation I. Effects on dams' metabolism and pups' body weight gainen
dc.typeinfo:eu-repo/semantics/article
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