AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

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dc.contributor.authorDubiela, Francisco Paulino [UNIFESP]
dc.contributor.authorQueiroz, Claudio Marcos
dc.contributor.authorMoreira, Karin Di Monteiro [UNIFESP]
dc.contributor.authorNobrega, Jose N.
dc.contributor.authorSita, Luciane Valeria
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorHipólide, Débora Cristina [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionCtr Addict & Mental Hlth
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:34:43Z
dc.date.available2016-01-24T14:34:43Z
dc.date.issued2013-11-15
dc.description.abstractThe present study addressed the effects of sleep deprivation (SD) on AMPA receptor (AMPAR) binding in brain regions associated with learning and memory, and investigated whether treatment with drugs acting on AMPAR could prevent passive avoidance deficits in sleep deprived animals. [H-3]AMPA binding and GluR1 in situ hybridization signals were quantified in different brain regions of male Wistar rats either immediately after 96 h of sleep deprivation or after 24 h of sleep recovery following 96 h of sleep deprivation. Another group of animals were sleep deprived and then treated with either the AMPAR potentiator, aniracetam (25, 50 and 100 mg/kg, acute administration) or the AMPAR antagonist GYKI-52466 (5 and 10 mg/kg, acute and chronic administration) before passive avoidance training. Task performance was evaluated 2 h and 24 h after training. A significant reduction in [H-3]AMPA binding was found in the hippocampal formation of SD animals, while no alterations were observed in GluR1 mRNA levels. the highest dose of aniracetam (100 mg/kg) reverted SD-induced impairment of passive avoidance performance in both retention tests, whereas GYKI-52466 treatment had no effect. Pharmacological enhancement of AMPAR function may revert hippocampal-dependent learning impairments produced after SD. We argue that such effects might be associated with reduced AMPAR binding in the hippocampus of sleep deprived animals. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Inst Brain, BR-59072970 Natal, RN, Brazil
dc.description.affiliationCtr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON, Canada
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Anat, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa
dc.description.sponsorshipIDFAPESP: 1998/1403-3
dc.description.sponsorshipIDFAPESP: 2007/53176-8
dc.description.sponsorshipIDFAPESP: 2011/09816-8
dc.format.extent189-196
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2013.09.037
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 257, p. 189-196, 2013.
dc.identifier.doi10.1016/j.bbr.2013.09.037
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36983
dc.identifier.wosWOS:000328519200024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep deprivationen
dc.subjectAMPA receptoren
dc.subjectPassive avoidance tasken
dc.subjectAniracetamen
dc.subjectGYKI-52466en
dc.titleAMPA receptors mediate passive avoidance deficits induced by sleep deprivationen
dc.typeinfo:eu-repo/semantics/article
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