Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disorders

Página do item simplificado
dc.contributor.authorMorshed, S. A.
dc.contributor.authorParveen, S.
dc.contributor.authorLeckman, J. F.
dc.contributor.authorMercadante, M. T.
dc.contributor.authorKiss, MHB
dc.contributor.authorMiguel, E. C.
dc.contributor.authorArman, A.
dc.contributor.authorYazgan, Y.
dc.contributor.authorFujii, T.
dc.contributor.authorPaul, S.
dc.contributor.authorPeterson, B. S.
dc.contributor.authorZhang, H. P.
dc.contributor.authorKing, R. A.
dc.contributor.authorScahill, L.
dc.contributor.authorLombroso, P. J.
dc.contributor.institutionYale Univ
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionIstanbul Univ
dc.contributor.institutionKeio Univ
dc.date.accessioned2016-01-24T12:31:30Z
dc.date.available2016-01-24T12:31:30Z
dc.date.issued2001-10-15
dc.description.abstractBackground: Some cases of Tourette's syndrome (TS) are hypothesized to be caused by autoantibodies that develop in response to a preceding group A beta hemolytic streptococcal infection.Methods: To test this hypothesis, we looked for the presence ot total and IgG antibodies against neural, nuclear, cytoskeletal and streptococcal epitopes using indirect immunofluorescent assays and Western blot techniques in three patient groups: TS (n = 81), SC (n = 27), and a group of autoimmune disorders (n = 52) and in normal controls (n = 67). Subjects were ranked after titrations of autoantibodies from 0 to 227 according to their level of immunoreactivity.Results: TS patients had a significantly higher mean rank for total antineural and antinuclear antibodies, as well as antistreptolysin 0 titers. However, among children and adolescents, only the total antinuclear antibodies were increased in TS patients compared to age matched controls. Compared to SC patients, TS patients had a significantly lower mean rank for total and IgG class antineural antibodies, significantly lower IgG class anticytoskeletal antibodies, and a significantly higher rank for total antinuclear antibodies. Compared to a mixed group of autoimmune disorders, the TS patients had a significantly lower mean rank for total and IgG class antineural antibodies, total and IgG class antinuclear antibodies, IgG class anticytoskeletal antibodies, and a significantly higher rank for antistreptococcal antibodies.Conclusions: TS patients had significantly higher levels of total antineural and antinuclear antibodies than did controls. Their relation to IgG class antineural and antinuclear antibodies, markers for prior streptococcal infection, and other clinical characteristics, especially chronological age, was equivocal. (C) 2001 Society of Biological Psychiatry.en
dc.description.affiliationYale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Childrens Clin Res Ctr, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Nursing, New Haven, CT 06536 USA
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationIstanbul Univ, Marmara Hosp, Dept Psychiat, Istanbul, Turkey
dc.description.affiliationKeio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
dc.description.sourceWeb of Science
dc.format.extent566-577
dc.identifierhttp://dx.doi.org/10.1016/S0006-3223(01)01096-4
dc.identifier.citationBiological Psychiatry. New York: Elsevier B.V., v. 50, n. 8, p. 566-577, 2001.
dc.identifier.doi10.1016/S0006-3223(01)01096-4
dc.identifier.issn0006-3223
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26643
dc.identifier.wosWOS:000171812700002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectautoantibodiesen
dc.subjectmolecular mimicryen
dc.subjectneuropsychiatric disordersen
dc.subjectTourette's syndromeen
dc.subjectSydenham's choreaen
dc.subjectautoimmune disordersen
dc.titleAntibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disordersen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral