Acute Hepatitis C in Brazil: Results of a National Survey

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dc.contributor.authorPaiva Ferreira, Adalgisa de Souza
dc.contributor.authorPerez, Renata de Mello
dc.contributor.authorGomes Ferraz, Maria Lucia [UNIFESP]
dc.contributor.authorLewis-Ximenez, Lia Laura
dc.contributor.authorPereira, Joao Luis
dc.contributor.authorLerias de Almeida, Paulo Roberto
dc.contributor.authorMattos, Angelo Alves de
dc.contributor.authorAcute Hepatitis C Study Grp Brazil
dc.contributor.institutionUniv Fed Maranhao
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionOsvaldo Cruz Fdn
dc.contributor.institutionGen Hosp Bonsucesso
dc.contributor.institutionNossa Senhora Conceicao Hosp
dc.contributor.institutionFed Fdn Sch Med Sci
dc.date.accessioned2016-01-24T14:17:15Z
dc.date.available2016-01-24T14:17:15Z
dc.date.issued2011-10-01
dc.description.abstractThe incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. the objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A questionnaire was sent to all members of the Brazilian Society of Hepatology. Sixteen centers participated with a total of 170 cases between 2000 and 2008. Among them, 37 had chronic renal failure on hemodialysis and were evaluated separately. the main diagnostic criterion in non-uremic patients was ALT (alanine aminotransferase) elevation associated with risk factors. in patients with chronic renal failure, anti-hepatitis C virus (HCV) sero-conversion was the most frequent criterion. Among the 133 non-uremic patients the main risk factors were hospital procedures, whereas in hemodialysis patients, dialysis was the single risk factor in 95% of the cases. Jaundice was more frequent in non-uremic patients (82% vs. 13%; P < 0.001) and ALT levels were higher in these individuals (P < 0.001). Spontaneous clearance was more frequent in non-uremic patients (51% vs. 3%; P < 0.001). Sixty-five patients were treated: 39 non-urennic patients and 26 on dialysis. Sustained virological response rates were 60% for non-uremic and 58% for uremic patients (P = 0.98). There was no association of these rates with the study variables. These findings show that cases of acute hepatitis C are still occurring and have been related predominantly to hospital procedures. Measures to prevent nosocomial transmission should be adopted rigorously and followed to minimize this important source of infection observed in this survey. J. Med. Virol. 83:1738-1743, 2011. (C) 2011 Wiley-Liss, Inc. J. Med.en
dc.description.affiliationUniv Fed Maranhao, Sao Luis, MA, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationOsvaldo Cruz Fdn, Rio de Janeiro, Brazil
dc.description.affiliationGen Hosp Bonsucesso, Rio de Janeiro, Brazil
dc.description.affiliationNossa Senhora Conceicao Hosp, Porto Alegre, RS, Brazil
dc.description.affiliationFed Fdn Sch Med Sci, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1738-1743
dc.identifierhttp://dx.doi.org/10.1002/jmv.22175
dc.identifier.citationJournal of Medical Virology. Malden: Wiley-Blackwell, v. 83, n. 10, p. 1738-1743, 2011.
dc.identifier.doi10.1002/jmv.22175
dc.identifier.issn0146-6615
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34084
dc.identifier.wosWOS:000293985900009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Medical Virology
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectacute hepatitis Cen
dc.subjectBrazilen
dc.subjectepidemiologyen
dc.subjectHCVen
dc.subjectrisk factorsen
dc.titleAcute Hepatitis C in Brazil: Results of a National Surveyen
dc.typeArtigo
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