Prevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazil

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dc.citation.issue6
dc.citation.volume20
dc.contributor.authorRizzo, Silvia Renata Cornelio Parolin [UNIFESP]
dc.contributor.authorGazito, Diana
dc.contributor.authorPott-Junior, Henrique [UNIFESP]
dc.contributor.authorMoreira Latini, Flavia Roche
dc.contributor.authorCastelo, Adauto [UNIFESP]
dc.coverageRio De Janeiro
dc.date.accessioned2020-07-31T12:47:22Z
dc.date.available2020-07-31T12:47:22Z
dc.date.issued2016
dc.description.abstractThe recent development of interferon-free regimens based on direct-acting antivirals for the treatment of chronic hepatitis C virus infection has benefited many but not all patients. Some patients still experience treatment failure, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism. The present study assessed the prevalence of rs12979860-CC, rs12979860-CT, and rs12979860-TT genotypes of the IFNL3 gene, and its relationship with ancestry informative markers in 949 adult Brazilian healthy blood donors. Race was analyzed using ancestry informative markers as a surrogate for ancestry. IFNL3 gene was genotyped using the ABI TaqMan single nucleotide polymorphisms genotyping assays. The overall frequency of rs12979860-CC genotype was 36.9%. The contribution of African ancestry was significantly higher among donors from the northeast region in relation to southeast donors, whereas the influence of European ancestry was significantly higher in southeast donors. Donors with rs12979860-CC and rs12979860-CT genotypes had similar ancestry background. The contribution of African ancestry was higher among rs12979860-TT genotype donors in comparison to both rs12979860-CC and rs12979860-CT genotypes. The prevalence of rs12979860-CC genotype is similar to that found in the US, despite the Brazilian ancestry informative markers admixture. However, in terms of ancestry, rs12979860-CT genotype was much closer to rs12979860-CC individuals than to rs12979860-TT. (C) 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.en
dc.description.affiliationAssoc Beneficente Coleta Sangue Colsan, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo (Unifesp), Departamento de Medicina, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent619-622
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2016.10.002
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 20, n. 6, p. 619-622, 2016.
dc.identifier.doi10.1016/j.bjid.2016.10.002
dc.identifier.issn1413-8670
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56776
dc.identifier.wosWOS:000389965800014
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAncestry informative markersen
dc.subjectChronic hepatitis C virus infectionen
dc.subjectDirect-acting antiviralsen
dc.subjectSingle nucleotide polymorphismsen
dc.titlePrevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazilen
dc.typeinfo:eu-repo/semantics/article
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