Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?

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dc.contributor.authorLobo, Vera Lúcia Rodrigues [UNIFESP]
dc.contributor.authorSoares Júnior, José Maria [UNIFESP]
dc.contributor.authorSimões, Manuel de Jesus [UNIFESP]
dc.contributor.authorSimões, Ricardo dos Santos [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:38:17Z
dc.date.available2015-06-14T13:38:17Z
dc.date.issued2008-01-01
dc.description.abstractOBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen's effects on rat peritoneal endometrial implants.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Ginecologia
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Departamento de Obstetrícia e Ginecologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Morfologia
dc.description.affiliationUnifespUNIFESP, Depto. de Ginecologia
dc.description.affiliationUnifespUNIFESP, Depto. de Morfologia
dc.description.sourceSciELO
dc.format.extent525-530
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322008000400019
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 63, n. 4, p. 525-530, 2008.
dc.identifier.doi10.1590/S1807-59322008000400019
dc.identifier.fileS1807-59322008000400019.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322008000400019
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4143
dc.identifier.wosWOS:000258504600019
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsAcesso aberto
dc.subjectExperimental endometriosisen
dc.subjectPeritoneal implantsen
dc.subjectOvariectomized ratsen
dc.subjectGestrinoneen
dc.subjectEstrogenen
dc.titleDoes gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?en
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