Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus

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dc.contributor.authorPeracchi, Octávio Augusto Bedin [UNIFESP]
dc.contributor.authorTerreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.authorMunekata, Regina Viviane [UNIFESP]
dc.contributor.authorLen, Claudio Arnaldo [UNIFESP]
dc.contributor.authorSarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.authorLazaretti-Castro, Marise [UNIFESP]
dc.contributor.authorHilário, Maria Odete Esteves [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:47:14Z
dc.date.available2015-06-14T13:47:14Z
dc.date.issued2014-08-01
dc.description.abstractWe evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Unidade de Reumatologia Pediátrica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de Endocrinologia
dc.description.affiliationUnifespUNIFESP, Depto. de Pediatria
dc.description.affiliationUnifespUNIFESP, Depto. de Pediatria Unidade de Reumatologia Pediátrica
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Divisão de Endocrinologia
dc.description.sourceSciELO
dc.format.extent721-726
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20143948
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 721-726, 2014.
dc.identifier.doi10.1590/1414-431X20143948
dc.identifier.fileS0100-879X2014000800721.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2014000800721
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8526
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectJuvenile systemic lupus erythematosusen
dc.subjectVitamin Den
dc.subjectCalciumen
dc.subjectBone metabolismen
dc.subjectParathormoneen
dc.titleLow serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosusen
dc.typeinfo:eu-repo/semantics/article
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