Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models

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dc.contributor.authorCastro, Pollyanna Celso F. de
dc.contributor.authorHoshino, Alberto
dc.contributor.authorSilva, Jair Campos da
dc.contributor.authorMendes, Fulvio Rieli
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCESUPA
dc.contributor.institutionUEPA
dc.date.accessioned2016-01-24T13:48:37Z
dc.date.available2016-01-24T13:48:37Z
dc.date.issued2007-05-01
dc.description.abstractSeveral species of the genus Passiflora, known in Brazil as 'maracuja', have widespread use in folk medicine as sedatives and anxiolytics. the anxiolytic activities of aqueous and hydroalcohol extracts of Passiflora quadrangularis leaves were evaluated using the elevated plus-maze, open held and holeboard tests. the hydroalcohol extract presented results suggestive of anxiolytic activity in dosages around 100, 250 and 500 mg/kg, as expressed by elevation of the time spent on the open arms in the plus-maze; a decrease of freezing and an increase of deambulation and rearing in the open field lest. the hydroalcohol extract showed results similar to diazepam on the holeboard. No positive results were found for the aqueous extract. Copyright (c) 2007 John Wiley & Sons, Ltd.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationCESUPA, Lab Phytochem, Belem, Para, Brazil
dc.description.affiliationUEPA, Pharmacol Lab, Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent481-484
dc.identifierhttp://dx.doi.org/10.1002/ptr.2079
dc.identifier.citationPhytotherapy Research. Chichester: John Wiley & Sons Ltd, v. 21, n. 5, p. 481-484, 2007.
dc.identifier.doi10.1002/ptr.2079
dc.identifier.issn0951-418X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29688
dc.identifier.wosWOS:000246163500018
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPhytotherapy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectPassinoraceaeen
dc.subjectPassiflora quadrangularisen
dc.subjectanxiolytic activityen
dc.subjectelevated plus-mazeen
dc.subjectopen fielden
dc.subjectratsen
dc.titlePossible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental modelsen
dc.typeinfo:eu-repo/semantics/article
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