A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid

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dc.contributor.authorSantos, V.n. [UNIFESP]
dc.contributor.authorLanzoni, Valeria Pereira [UNIFESP]
dc.contributor.authorSzejnfeld, Jacob [UNIFESP]
dc.contributor.authorShigueoka, David Carlos [UNIFESP]
dc.contributor.authorParise, Edison Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:03Z
dc.date.available2015-06-14T13:30:03Z
dc.date.issued2003-06-01
dc.description.abstractIn order to determine the effect of ursodeoxycholic acid on nonalcoholic fatty liver disease, 30 patients with body mass indices higher than 25, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) or gamma-glutamyltransferase (gamma-GT) at least more than 1.5 times the upper limit of normality, and hepatic steatosis demonstrated by ultrasonography were randomized into two groups of 15 patients to receive placebo or 10 mg kg-1 day-1 ursodeoxycholic acid for three months. Abdominal computed tomography was performed to quantify hepatic fat content, which was significantly correlated with histological grading of steatosis (r s = -0.83, P < 0.01). Patient body mass index remained stable for both groups throughout the study, but a significant reduction in mean (± SEM) serum levels of ALT, AST and gamma-GT was observed only in the treated group (ALT = 81.2 ± 9.7, 44.8 ± 7.7, 48.1 ± 7.7 and 52.2 ± 6.3 IU/l at the beginning and after the first, second and third months, respectively, N = 14, P < 0.05). For the placebo group ALT values were 66.4 ± 9.8, 54.5 ± 7, 60 ± 7.6 and 43.7 ± 5 IU/l, respectively. No alterations in hepatic lipid content were observed in these patients by computed tomography examination (50.2 ± 4.2 Hounsfield units (HU) at the beginning versus 51.1 ± 4.1 HU at the third month). These results show that ursodeoxycholic acid is able to reduce serum levels of hepatic enzymes in patients with nonalcoholic fatty liver disease, but this effect is not related to modifications in liver fat content.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Diagnóstico por Imagem
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Patologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Medicina
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Diagnóstico por Imagem
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Patologia
dc.description.sourceSciELO
dc.format.extent723-729
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003000600007
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 6, p. 723-729, 2003.
dc.identifier.doi10.1590/S0100-879X2003000600007
dc.identifier.fileS0100-879X2003000600007.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2003000600007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1764
dc.identifier.wosWOS:000183866400007
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNonalcoholic fatty liver diseaseen
dc.subjectNonalcoholic steatohepatitisen
dc.subjectFatty liveren
dc.subjectUrsodeoxycholic aciden
dc.titleA randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic aciden
dc.typeinfo:eu-repo/semantics/article
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