The persistence of multifocal colonisation by a single ABC genotype of Candida albicans may predict the transition from commensalism to infection

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dc.contributor.authorChaves, Guilherme Maranhão [UNIFESP]
dc.contributor.authorSantos, Fernanda Pahim [UNIFESP]
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:43:37Z
dc.date.available2015-06-14T13:43:37Z
dc.date.issued2012-03-01
dc.description.abstractCandida albicans is a common member of the human microbiota and may cause invasive disease in susceptible populations. Several risk factors have been proposed for candidaemia acquisition. Previous Candida multifocal colonisation among hospitalised patients may be crucial for the successful establishment of candidaemia. Nevertheless, it is still not clear whether the persistence or replacement of a single clone of C. albicans in multiple anatomical sites of the organism may represent an additional risk for candidaemia acquisition. Therefore, we prospectively evaluated the dynamics of the colonising strains of C. albicans for two groups of seven critically ill patients: group I included patients colonised by C. albicans in multiple sites who did not develop candidaemia and group II included patients who were colonised and who developed candidaemia. ABC and microsatellite genotyping of 51 strains of C. albicans revealed that patients who did not develop candidaemia were multiply colonised by at least two ABC genotypes of C. albicans, whereas candidaemic patients had highly related microsatellites and the same ABC genotype in colonising and bloodstream isolates that were probably present in different body sites before the onset of candidaemia.en
dc.description.affiliationUniversidade Federal do Rio Grande do Norte Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Laboratório Especial de Micologia
dc.description.affiliationUnifespUNIFESP, Laboratório Especial de Micologia
dc.description.sourceSciELO
dc.format.extent198-204
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762012000200008
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 2, p. 198-204, 2012.
dc.identifier.doi10.1590/S0074-02762012000200008
dc.identifier.fileS0074-02762012000200008.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02762012000200008
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6982
dc.identifier.wosWOS:000301463500008
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCandida albicansen
dc.subjectgenotypingen
dc.subjectcolonisationen
dc.subjectbloodstream infectionen
dc.subjectstrain maintenance or replacementen
dc.titleThe persistence of multifocal colonisation by a single ABC genotype of Candida albicans may predict the transition from commensalism to infectionen
dc.typeinfo:eu-repo/semantics/article
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