Leukocyte telomere length variation in different stages of schizophrenia

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dc.citation.volume96
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorRizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.authorXavier, Gabriela [UNIFESP]
dc.contributor.authorTempaku, Priscila Farias [UNIFESP]
dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorSantoro, Marcos L. [UNIFESP]
dc.contributor.authorSpindola, Leticia M. [UNIFESP]
dc.contributor.authorMoretti, Patricia S. [UNIFESP]
dc.contributor.authorMazzotti, Diego R.
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorGouvea, Eduardo S.
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorMaes, Michael
dc.contributor.authorCordeiro, Quirino
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-02T18:52:12Z
dc.date.available2020-07-02T18:52:12Z
dc.date.issued2018
dc.description.abstractRecent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naive FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald chi(2) = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald chi(2) = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although the exact pathways underlying longer TL in SCZ patients remain unclear, these findings raise more questions than answers and suggest that TL may be of immense value on SCZ progression. Further studies are required to investigate the association of TL in FEP and SCZ.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida, India
dc.description.affiliationRes Grp Behav & Mol Neurosci Bipolar Disorder, Silo Paulo, Brazil
dc.description.affiliationProgram Recognit & Intervent Individuals At Risk, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Misericordia Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Londrina, Graduat Program Hlth Sci, Londrina, PR, Brazil
dc.description.affiliationChulalongkorn Univ, Dept Psychiat, Bangkok, Thailand
dc.description.affiliationChildrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespSanta Casa Misericordia Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) - Brazil
dc.description.sponsorshipCoordination of Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq), Brazil
dc.description.sponsorshipIDFAPESP: 2014/07280-1
dc.description.sponsorshipIDFAPESP: 2010/08968-6
dc.description.sponsorshipIDCNPq: 457217/2014-6
dc.format.extent218-223
dc.identifierhttp://dx.doi.org/10.1016/j.jpsychires.2017.10.016
dc.identifier.citationJournal Of Psychiatric Research. Oxford, v. 96, p. 218-223, 2018.
dc.identifier.doi10.1016/j.jpsychires.2017.10.016
dc.identifier.fileWOS000419412800029.pdf
dc.identifier.issn0022-3956
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53945
dc.identifier.wosWOS:000419412800029
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofJournal Of Psychiatric Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTelomere lengthen
dc.subjectFirst-episode psychosisen
dc.subjectSchizophreniaen
dc.subjectProgressionen
dc.titleLeukocyte telomere length variation in different stages of schizophreniaen
dc.typeinfo:eu-repo/semantics/article
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