Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure

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dc.citation.volume8
dc.contributor.authorManchini, Martha T. [UNIFESP]
dc.contributor.authorAntonio, Ednei L. [UNIFESP]
dc.contributor.authorSilva Junior, Jose Antonio
dc.contributor.authorde Carvalho, Paulo de Tarso C.
dc.contributor.authorAlbertini, Regiane [UNIFESP]
dc.contributor.authorPereira, Fernando C.
dc.contributor.authorFeliciano, Regiane
dc.contributor.authorMontemor, Jairo [UNIFESP]
dc.contributor.authorVieira, Stella S. [UNIFESP]
dc.contributor.authorGrandinetti, Vanessa
dc.contributor.authorYoshizaki, Amanda [UNIFESP]
dc.contributor.authorChaves, Marcio
dc.contributor.authorda Silva, Moises P.
dc.contributor.authorde Lima, Rafael do Nascimento
dc.contributor.authorBocalini, Danilo S.
dc.contributor.authorde Melo, Bruno L. [UNIFESP]
dc.contributor.authorTucci, Paulo J. F. [UNIFESP]
dc.contributor.authorSerra, Andrey J. [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-17T14:03:13Z
dc.date.available2020-07-17T14:03:13Z
dc.date.issued2017
dc.description.abstractLow-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations. Female Wistar rats were subjected to the coronary occlusion to induce myocardial infarction or Sham operation. A single LLLT application was carried out after 60 s and 3 days post-coronary occlusion, respectively. Echocardiography was performed 3 days and at the end of the experiment (5 weeks) to evaluate cardiac function. After the last echocardiographic examination. LV hemodynamic evaluation was performed at baseline and on sudden afterload increases. Compared with the Sham group, infarcted rats showed increased systolic and diastolic internal diameter as well as a depressed shortening fraction of LV. The only benefit of the LLLT was a higher shortening fraction after 3 days of infarction. However, treated-LLLT rats show a lower shortening fraction in the 5th week of study when compared with Sham and non-irradiated rats. A worsening of cardiac function was confirmed in the hemodynamic analysis as evidenced by the higher LV end-diastolic pressure and lower +dP/dt and dP/dt with five weeks of study. Cardiac functional reserve was also impaired by infarction as evidenced by an attenuated response of stroke work index and cardiac output to a sudden afterload stress, without LLLT repercussions. No significant differences were found in the myocardial expression of Akti NEGF pathway. Collectively, these findings illustrate that LLLT improves LV systolic function in the early post-infarction cardiac remodeling. However, this beneficial effect may be dependent on the maintenance of phototherapy. Long-term studies with LLLT application are needed to establish whether these effects ultimately translate into improved cardiac remodeling.en
dc.description.affiliationNove de Julho Univ, Lab Biophoton, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationNove de Julho Univ, Program Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Brazil Phys Educ & Aging Sci Program, Translat Physiol Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDCNPq: 4400851/2014-8
dc.description.sponsorshipIDFAPESP: 09-54225/8
dc.description.sponsorshipIDFAPESP: 15/11028-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphys.2017.00023
dc.identifier.citationFrontiers In Physiology. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fphys.2017.00023
dc.identifier.fileWOS000392869500001.pdf
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55230
dc.identifier.wosWOS:000392869500001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectangiogenesisen
dc.subjectcardiac remodelingen
dc.subjectcardiac performanceen
dc.subjectlow-level laser therapyen
dc.subjectmyocardial infarctionen
dc.titleLow-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failureen
dc.typeinfo:eu-repo/semantics/article
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