Use of benzodiazepines in obsessive-compulsive disorder

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dc.contributor.authorStarcevic, Vladan
dc.contributor.authorBerle, David
dc.contributor.authordo Rosario, Maria Conceicao [UNIFESP]
dc.contributor.authorBrakoulias, Vlasios
dc.contributor.authorFerrao, Ygor A.
dc.contributor.authorViswasam, Kirupamani
dc.contributor.authorShavitt, Roseli
dc.contributor.authorMiguel, Euripedes
dc.contributor.authorFontenelle, Leonardo F.
dc.date.accessioned2018-07-26T17:30:31Z
dc.date.available2018-07-26T17:30:31Z
dc.date.issued2016
dc.description.abstractThis study aimed to determine the frequency of benzodiazepine (BDZ) use in a large sample of patients with obsessive-compulsive disorder (OCD) and ascertain the type of BDZ used and the correlates and predictors of BDZ use in OCD. The sample consisted of 955 patients with OCD from a comprehensive, cross-sectional, multicentre study conducted by the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders between 2003 and 2009. The rate of BDZ use over time in this OCD sample was 38.4%. Of individuals taking BDZs, 96.7% used them in combination with other medications, usually serotonin reuptake inhibitors. The most commonly used BDZ was clonazepam. Current age, current level of anxiety and number of additional medications for OCD taken over time significantly predicted BDZ use. This is the first study to comprehensively examine BDZ use in OCD patients, demonstrating that it is relatively common, despite recommendations from treatment guidelines. Use of BDZs in combination with several other medications over time and in patients with marked anxiety suggests that OCD patients taking BDZs may be more complex and more difficult to manage. This calls for further research and clarification of the role of BDZs in the treatment of OCD.en
dc.description.affiliationDiscipline of Psychiatry, Sydney Medical School – Nepean, University of Sydney, Sydney, NSW 2006, Australia
dc.description.affiliationSchool of Psychiatry, UNSW Australia, Randwick
dc.description.affiliationSt John of God Health Care, Richmond Hospital, North Richmond
dc.description.affiliationDepartment of Psychiatry, Nepean Hospital, Penrith, New South Wales, 2751, Australia
dc.description.affiliationSchool of Psychological Sciences, Monash University, Melbourne, Victoria, 3004, Australia
dc.description.affiliationDepartment of Psychiatry, Federal University of São Paulo, Brazil
dc.description.affiliationObsessive-Compulsive Spectrum Disorders Project, Institute and Department of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil
dc.description.affiliationDepartment of Psychiatry, Federal University of Health Sciences of Porto Alegre, Rio Grande do Sul, Brazil
dc.description.affiliationAnxiety and Obsessive-Compulsive Spectrum Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, D’Or Institute for Research and Education, Rio de Janeiro, Brazil
dc.description.affiliationUnifespDepartment of Psychiatry, Federal University of São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 573974/2008-0
dc.description.sponsorshipIDFAPESP: 2005/55628-8
dc.format.extent27-33
dc.identifierhttp://dx.doi.org/10.1097/YIC.0000000000000100
dc.identifier.citationInternational Clinical Psychopharmacology. Philadelphia, v. 31, n. 1, p. 27-33, 2016.
dc.identifier.doi10.1097/YIC.0000000000000100
dc.identifier.issn0268-1315
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/46095
dc.identifier.wosWOS:000366691200004
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofInternational Clinical Psychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectanxietyen
dc.subjectbenzodiazepinesen
dc.subjectclonazepamen
dc.subjectobsessive-compulsive disorderen
dc.subjecttreatment guidelinesPharmacological-Treatmenten
dc.subjectPosttraumatic-Stressen
dc.subjectClonazepam Treatmenten
dc.subjectPanic Disorderen
dc.subjectAnxietyen
dc.subjectPopulationen
dc.subjectBrazilen
dc.subjectClomipramineen
dc.subjectGuidelinesen
dc.subjectPatternsen
dc.titleUse of benzodiazepines in obsessive-compulsive disorderen
dc.typeinfo:eu-repo/semantics/article
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