RELATIONSHIP BETWEEN PERIPHERAL MUSCLE STRUCTURE and FUNCTION in PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH DIFFERENT NUTRITIONAL STATUS

dc.contributor.authorMalaguti, Carla [UNIFESP]
dc.contributor.authorNapolis, Lara M. [UNIFESP]
dc.contributor.authorVillaca, Debora [UNIFESP]
dc.contributor.authorNeder, Jose A. [UNIFESP]
dc.contributor.authorNery, Luiz E. [UNIFESP]
dc.contributor.authorDal Corso, Simone [UNIFESP]
dc.contributor.institutionNove Julho Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:00Z
dc.date.available2016-01-24T14:17:00Z
dc.date.issued2011-07-01
dc.description.abstractMalaguti, C, Napolis, LM, Villaca, D, Neder, JA, Nery, LE, and Dal Corso, S. Relationship between peripheral muscle structure and function in patients with chronic obstructive pulmonary disease with different nutritional status. J Strength Cond Res 25(7): 1795-1803, 2011-The purpose of this study was to investigate the relationships between peripheral muscle structure (mass) and function (strength, endurance, and maximal aerobic capacity) in patients with chronic obstructive pulmonary disease (COPD) with different nutritional states. Thirty-nine patients (31 male) with moderate-severe COPD (63.5 +/- 7.3 [SD] years) and 17 controls (14 male; 64.7 +/- 5.5 [SD] years) underwent isokinetic (peak torque [PT]), isometric (isometric torque [IT]), and endurance strength (total work [TW]) measurements of the knee extensor muscles and a maximal cardiopulmonary exercise test to evaluate the maximal aerobic capacity (peak oxygen uptake [<(V)over dot>O-2] peak). Muscle mass (MM) was determined using dual-energy x-ray absorptiometry. Patients with COPD presented with reduced muscle function as compared with the healthy controls: PT (105.9 +/- 33.9 vs. 134.3 +/- 30.9, N.m(-1), respectively, p < 0.05), TW (1,446.3 +/- 550.8 vs. 1,792.9 +/- 469.1 kJ, respectively, p < 0.05), and <(V)over dot>(2)peak (68.1 +/- 15.1 vs. 93.7 +/- 14.5, % pred, respectively, p, 0.05). Significant relationships were found between muscle structure and function (strength and endurance) in the patient subgroup with preserved MM and in the control group: PT.MM-1(r(2) = 0.36; p = 0.01 vs. r(2) = 0.32; p = 0.01, respectively) and TW.MM-1 (r(2) = 0.32; p = 0.01 vs. r(2) = 0.22; p = 0.05, respectively). Strength corrected for mass normalized this function in both patient subgroups, whereas endurance was normalized only in the patient subgroup without muscle depletion. Maximal aerobic capacity remained reduced, despite the correction, in both patient subgroups (depleted or nondepleted) compared with the healthy controls (<(V)over dot>(2)peak.MM-1: 9.1 +/- 3.7 vs. 21.8 +/- 4.9 vs. 28.5 +/- 4.2 ml.min.kg(-1), respectively, with p < 0.01 among groups). Muscle atrophy seems to be the main determinant of strength reduction among patients with moderate-severe COPD, whereas endurance reduction seems to be more related to imbalance between oxygen delivery and consumption than to the local muscle structure itself. Peripheral MM did not constitute a good predictor for maximal aerobic capacity in this population. the main practical application of this study is to point out a crucial role for the strategies able to ameliorate cardiorespiratory and muscular fitness in patients with COPD, even in those patients with preserved MM.en
dc.description.affiliationNove Julho Univ, Dept Hlth, Rehabil Sci Masters Program, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit SEFICE, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit SEFICE, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNove de Julho University
dc.format.extent1795-1803
dc.identifierhttp://dx.doi.org/10.1519/JSC.0b013e3181e501c1
dc.identifier.citationJournal of Strength and Conditioning Research. Philadelphia: Lippincott Williams & Wilkins, v. 25, n. 7, p. 1795-1803, 2011.
dc.identifier.doi10.1519/JSC.0b013e3181e501c1
dc.identifier.issn1064-8011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33882
dc.identifier.wosWOS:000292024000006
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Strength and Conditioning Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectenduranceen
dc.subjectexercise testingen
dc.subjectmuscle massen
dc.subjectmuscle strengthen
dc.titleRELATIONSHIP BETWEEN PERIPHERAL MUSCLE STRUCTURE and FUNCTION in PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH DIFFERENT NUTRITIONAL STATUSen
dc.typeinfo:eu-repo/semantics/article
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