Serum level of serotonin during real and during exercise in paraplegic patients

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dc.contributor.authorSteinberg, L. L. [UNIFESP]
dc.contributor.authorSposito, Maria de Matilde de Mello [UNIFESP]
dc.contributor.authorLauro, Flávio Antônio Ascânio [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorSilva, A. C.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Goias Catalao
dc.date.accessioned2016-01-24T12:30:30Z
dc.date.available2016-01-24T12:30:30Z
dc.date.issued1998-01-01
dc.description.abstractThe purpose of this study was to evaluate the serum level of serotonin (5-HT) during rest and response to exercise in subjects with spinal cord injury (SCI) with different levels of physical activity. Twenty-five male subjects with traumatic paraplegia, the neurological levels being between T1 and T12, volunteered for the study. They were divided into two groups matched for age, weight and time since injury, according to the level of physical activity: 14 inactive and 11 subjects regularly involved in sports activity and considered active. They all performed a maximal spiroergometric test with an arm crank ergometer. Two samples of blood were collected for 5-HT determination, during rest (PRE) and immediately after exercise test (POST). Serum 5-HT concentration was measured by high performance liquid chromatography using electrochemical detection (HPLC-ED). the results showed that peak oxygen uptake ((V) over dot O-2peak) was higher in the active group (27.08 +/- 2.60 vs 18.89 +/- 5.58 mL.kg(-1).min(-1), P<0.001). There were no significant differences between the inactive and active groups for the 5-HT PRE (respectively 176.96 and 193.73 ng.mL(-1), P>0.05) or POST values (275.44 vs 311.05 ng.mL(-1), P>0.05). Both groups showed an increment in 5-HT after maximal exercise, but only in the active group it reached statistical significance (Wilcoxon test, P<0.02). Our results show that chronic paraplegic individuals have normal resting serum serotonin levels and normal response to exercise. the relationship between training status, mood elevation and 5-HT in SCI could not be established in the present study, and further investigation is needed to clarify this issue.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthopaed & Traumatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniv Fed Goias Catalao, Goiania, Go, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthopaed & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent18-20
dc.identifierhttp://dx.doi.org/10.1038/sj.sc.3100516
dc.identifier.citationSpinal Cord. Basingstoke: Stockton Press, v. 36, n. 1, p. 18-20, 1998.
dc.identifier.doi10.1038/sj.sc.3100516
dc.identifier.issn1362-4393
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25831
dc.identifier.wosWOS:000071539600005
dc.language.isoeng
dc.publisherStockton Press
dc.relation.ispartofSpinal Cord
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectserotoninen
dc.subjectparaplegiaen
dc.subjectexerciseen
dc.subjectmonoaminesen
dc.subjectspinal cord injuryen
dc.titleSerum level of serotonin during real and during exercise in paraplegic patientsen
dc.typeinfo:eu-repo/semantics/article
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