Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats

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dc.contributor.authorBatista, M. L.
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorOliveira, E. M.
dc.contributor.authorSeelaender, M. C. L.
dc.contributor.authorRosa, L. F. B. P. Costa
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Mogi das Cruzes
dc.date.accessioned2016-01-24T13:48:37Z
dc.date.available2016-01-24T13:48:37Z
dc.date.issued2007-05-01
dc.description.abstractCongestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (M Phi s) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M Phi function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/wk, for 8-10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml . kg(-1). min(-1)), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. the resident and total cell number, the chemotaxis index, and the production of TNF-alpha stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M Phi function and induces beneficial metabolic effects in rats with post-MI CHF.en
dc.description.affiliationUniv São Paulo, Mol Biol Cell Grp, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Biodynam Human Body Movement, Sch Sport & Phys Educ, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Res Ctr Psychobiol & Sports, São Paulo, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Sch Phys Educ, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Res Ctr Psychobiol & Sports, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2033-2039
dc.identifierhttps://dx.doi.org/10.1152/japplphysiol.00871.2006
dc.identifier.citationJournal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 102, n. 5, p. 2033-2039, 2007.
dc.identifier.doi10.1152/japplphysiol.00871.2006
dc.identifier.issn8750-7587
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29682
dc.identifier.wosWOS:000248410600041
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofJournal of Applied Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPro-inflammatory cytokinesen
dc.subjectMigrationen
dc.subjectChemotaxis indexen
dc.subjectPhagocytic capacityen
dc.subjectExercise adaptationen
dc.subjectMyocardial infarctionen
dc.titleEndurance training restores peritoneal macrophage function in post-MI congestive heart failure ratsen
dc.typeinfo:eu-repo/semantics/article
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