Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae)

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dc.citation.issue3
dc.citation.volume28
dc.contributor.authorMorais, Thiago R. [UNIFESP]
dc.contributor.authorCoutinho, Ana Paula R. [UNIFESP]
dc.contributor.authorCamilo, Fernanda F. [UNIFESP]
dc.contributor.authorMartins, Tereza S. [UNIFESP]
dc.contributor.authorSartorelli, Patricia [UNIFESP]
dc.contributor.authorMassaoka, Mariana H. [UNIFESP]
dc.contributor.authorFigueiredo, Carlos R. [UNIFESP]
dc.contributor.authorLago, Joao Henrique G. [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:02:55Z
dc.date.available2020-07-17T14:02:55Z
dc.date.issued2017
dc.description.abstractThis work reports the application of an ionic liquid (1-butyl-3-methylimidazolium bromide, BMImBr) in the microwave assisted extraction (MAE) of metabolites from fruits of Schinus terebinthifolius. Dried fruits were individually extracted using BMImBr: H2O 1: 1, v/v (experiment 1) and pure H2O (experiment 2) by MAE (10 min at 60 degrees C). After partition using EtOAc, the yield to experiment 1 was about 23% while to experiment 2 was 0.1%. The EtOAc fraction obtained from experiment 1 was purified by chromatographic methods to afford 3-oxotirucalla-7,24Z-dien27- oic acid, 3a-hydroxytirucalla-7,24Z-dien-27-oic acid, 3 alpha-acetoxytirucalla-7,24Z-dien-27-oic acid, gallic acid, and ethyl gallate, being the first occurrence of the third compound as natural product. Cytotoxic activity was evaluated in vitro against cancer cell lines (A2058, HeLa, SiHa, HCT, SKBR-3, U87, and B16F2Nex2), being 3 alpha-acetoxytirucalla-7,24Z-dien-27-oic acid the more active metabolite with IC50 ranging from 10.9 +/- 1.3 to 17.3 +/- 1.4 mu g mL(-1), lower than that determined to positive control cisplatin.en
dc.description.affiliationInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), 09972-270 Diadema-SP, Brazil
dc.description.affiliationDepartamento de Micro, Imuno e Parasitologia, Universidade Federal de São Paulo (UNIFESP), 04023-062 São Paulo-SP, Brazil
dc.description.affiliationUnifespInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), 09972-270 Diadema-SP, Brazil
dc.description.affiliationUnifespDepartamento de Micro, Imuno e Parasitologia, Universidade Federal de São Paulo (UNIFESP), 04023-062 São Paulo-SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDFAPESP: BIOTA 2011/51739-6
dc.description.sponsorshipIDFAPESP: 2015/11936-2
dc.format.extent492-497
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20160215
dc.identifier.citationJournal Of The Brazilian Chemical Society. Sao Paulo, v. 28, n. 3, p. 492-497, 2017.
dc.identifier.doi10.21577/0103-5053.20160215
dc.identifier.fileWOS000394165800012.pdf
dc.identifier.issn0103-5053
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55086
dc.identifier.wosWOS:000394165800012
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal Of The Brazilian Chemical Society
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchinus terebinthifoliusen
dc.subjecttirucallane triterpenoidsen
dc.subjectgallic acid derivativesen
dc.subjectionic liquiden
dc.subjectMAEen
dc.subjectcytotoxic activityen
dc.titleApplication of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae)en
dc.typeinfo:eu-repo/semantics/article
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