Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats

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dc.contributor.authorHelrigle, Carla
dc.contributor.authorCamilo de Carvalho, Paulo deTarso
dc.contributor.authorCasalechi, Heliodora Leao
dc.contributor.authorPinto Leal-Junior, Ernesto Cesar
dc.contributor.authorCardoso Fernandes, Guilherme Henrique
dc.contributor.authorHelrigel, Panmera Almeida
dc.contributor.authorRabelo, Rogerio Leao
dc.contributor.authorAleixo-Junior, Ivo de Oliveira
dc.contributor.authorAimbire, Flavio [UNIFESP]
dc.contributor.authorAlbertini, Regiane
dc.date.accessioned2018-07-26T17:30:25Z
dc.date.available2018-07-26T17:30:25Z
dc.date.issued2016
dc.description.abstractThe aim of this experimental study was to investigate the effects of low-intensity light-emitting diode (LED) phototherapy on the inflammatory process in the calcaneal tendon of ovariectomized rats (OVX) through the involvement of the inflammatory mediators interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-alpha). Thirty-five female Wistar rats were divided into 4 groups: 3 groups of OVX rats totaling 30 rats (untreated OVX rats [OVX injury group], treated OVX rats [OVX LED group], and control OVX rats subgroups existed based on the sampling times, which were 3, 7, and 14 days) and 1 group of non-OVX rats (not OVX n = 5). Tendon injury was induced by trauma using a 208-g mass placed at 20 cm from the right tendon of each animal with energy of 0.70 J. The animals were treated 12 h after tendonitis with LED therapy and every 48 h thereafter until euthanasia (at 3, 7, or 14 days). The tendons were dissected and stored in liquid nitrogen at -196 A degrees C, thawed only at the time of immunoenzymatic testing (ELISA). Groups treated with LED showed a decrease in the number of pro-inflammatory cells, IL-6, and TNF-alpha (p < 0.05), and an increase in IL-10 (p < 0.05) when compared to the not OVX group (p < 0.05). It was concluded that low-intensity LED treatment using the parameters and wavelength of 945 nm in the time periods studied reduced the release of IL-6 and TNF-alpha and increased the release of IL-10, thereby improving the inflammatory response in OVX rats.en
dc.description.affiliationUniv Nove Julho, Postgrad Program Biophoton, Appl Hlth Sci, UNINOVE, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Nove Julho, Postgrad Program Rehabil Sci, UNINOVE, BR-01504001 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Goias UFG, Dept Vet Med, Jatai, Go, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Inst Sci & Technol ICT, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifespInstitute of Science and Technology - ICT- Federal University of São Paulo-UnifespSão José dos Campos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMulti Radiance Medical (Solon, OH, USA)
dc.format.extent33-40
dc.identifierhttp://dx.doi.org/10.1007/s10103-015-1821-7
dc.identifier.citationLasers In Medical Science. London, v. 31, n. 1, p. 33-40, 2016.
dc.identifier.doi10.1007/s10103-015-1821-7
dc.identifier.issn0268-8921
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/46067
dc.identifier.wosWOS:000367695100006
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers In Medical Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectInflammationen
dc.subjectOvariectomyen
dc.subjectLow-intensity LEDen
dc.subjectPhotobiomodulation therapyen
dc.subjectCalcaneal tendon injuryLevel Laser Therapyen
dc.subjectCollagenase-Induced Tendinitisen
dc.subjectEmitting Diode Therapyen
dc.subjectAchilles-Tendonen
dc.subjectExperimental-Modelen
dc.subjectEstrogen Deficiencyen
dc.subjectInjuryen
dc.subjectRepairen
dc.subjectNmen
dc.subjectPhototherapyen
dc.titleEffects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized ratsen
dc.typeinfo:eu-repo/semantics/article
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