Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients

dc.contributor.authorMorelli, V. M.
dc.contributor.authorLourenco, D. M.
dc.contributor.authorD'Almeida, V
dc.contributor.authorFranco, R. F.
dc.contributor.authorMiranda, F.
dc.contributor.authorZago, M. A.
dc.contributor.authorNoguti, MAE
dc.contributor.authorCruz, E.
dc.contributor.authorKerbauy, J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:33:21Z
dc.date.available2016-01-24T12:33:21Z
dc.date.issued2002-04-01
dc.description.abstractFasting total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation were evaluated in 91 patients with venous thromboembolism and without acquired thrombophilia, and in 91 age-matched and sex-matched controls. Hyperhomocysteinemia was detected in 11 patients (12.1%) and in two controls (2.2%), yielding an odds ratio (OR) for venous thrombosis of 6.1 [95% confidence interval (CI), 1.3-28.4]. After excluding 21 patients and four controls with other known genetic risk factors for venous thrombosis, the OR was not substantially changed (7.0; 95% Cl, 1.5-33.1). the prevalence of the MTHFR 677TT genotype was not significantly different in patients (9.9%) and in controls (5.5%), with an OR for venous thrombosis of 1.8 (95% CI, 0.6-5.8). Subjects with the MTHFR 677TT genotype showed higher levels of tHcy compared with the 677CC genotype in patients (P=0.010) and in controls (P=0.030). in conclusion, we found that fasting hyperhomocysteinemia is a risk factor for venous thrombosis in patients without known acquired thrombophilia and other genetic risk factors for venous thrombosis. Although tHcy levels are significantly higher in those homozygous for the MTHFR C677T mutation, this genotype does not increase the thrombotic risk in our study population. (C) 2002 Lippincott Williams Wilkins.en
dc.description.affiliationFed Univ São Paulo, Div Hematol, Dept Clin Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo, Dept Paediat, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo, Dept Surg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Clin Med, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUnifespFed Univ São Paulo, Div Hematol, Dept Clin Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo, Dept Paediat, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo, Dept Surg, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent271-275
dc.identifierhttp://dx.doi.org/10.1097/00001721-200204000-00014
dc.identifier.citationBlood Coagulation & Fibrinolysis. Philadelphia: Lippincott Williams & Wilkins, v. 13, n. 3, p. 271-275, 2002.
dc.identifier.doi10.1097/00001721-200204000-00014
dc.identifier.issn0957-5235
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26831
dc.identifier.wosWOS:000175547400014
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Coagulation & Fibrinolysis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjecthyperhomocysteinemiaen
dc.subjectmethylenetetrahydrofolate reductaseen
dc.subjectvenous thromboembolismen
dc.subjectBrazilianen
dc.subjectrisk factoren
dc.titleHyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patientsen
dc.typeinfo:eu-repo/semantics/article
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