Hormonal and behavioural responses of paradoxical sleep-deprived rats to the elevated plus maze

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dc.contributor.authorSuchecki, D.
dc.contributor.authorTiba, P. A.
dc.contributor.authorTufik, S.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:27Z
dc.date.available2016-01-24T12:33:27Z
dc.date.issued2002-07-01
dc.description.abstractActivation of the hypothalamic-pituitary-adrenal (HPA) axis is observed immediately after 96 in of paradoxical sleep (PS) deprivation. However, when individually or group PS-deprived rats are challenged with a mild stressor, they exhibit a facilitation of the corticosterone response, and a faster return to basal levels than control rats. Because the housing condition influences coping behaviour, we tested whether the type of PS deprivation (individually or in group) influenced anxiety-like behaviour in the elevated plus-maze and the accompanying adrenocorticotropin (ACTH) and corticosterone responses. Individually (I-DEP) or group deprived (G-DEP) rats and their appropriate control groups were either killed immediately after 96 h of sleep deprivation (time-point 0 or 'basal') or exposed to a 5-min test on the elevated plus maze and sampled 5, 20 or 60 min after test onset. Control of I-DEP rats showed reduced locomotor activity and augmented anxiety-like behaviour, replicating the effects of social isolation. Although I-DEP rats exhibited higher motor activity than cage control rats, these groups did not differ in regard to the percentage of entry and time spent in the open arms. G-DEP rats, in turn, ambulated more, entered and remained longer in the open arms, exhibiting less anxiety-like behaviour. PS-deprived rats exhibited higher ACTH and corticosterone 'basal' secretion than control rats. for all groups, peak ACTH secretion was reached at the 5-min time-point, returning to unstressed basal levels 60 min after the test, except for G-DEP rats, which showed a return at 20 min. Peak levels of corticosterone occurred at 5 min for PS-deprived groups and at 20 min for control groups. G-DEP rats showed a return to 'basal' unstressed levels at 20 min, whereas the I-DEP and control groups did so at 60 min. A negative correlation between exploration in the open arms and hormone concentrations was observed. These data indicate that housing condition influences the subsequent behaviour of PS-deprived rats in the EPM which, in turn, seems to determine the secretion profile of ACTH and corticosterone in response to the test.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent549-554
dc.identifierhttp://dx.doi.org/10.1046/j.1365-2826.2002.00812.x
dc.identifier.citationJournal of Neuroendocrinology. Oxford: Blackwell Publishing Ltd, v. 14, n. 7, p. 549-554, 2002.
dc.identifier.doi10.1046/j.1365-2826.2002.00812.x
dc.identifier.issn0953-8194
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26915
dc.identifier.wosWOS:000176669600004
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofJournal of Neuroendocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectparadoxical sleep deprivationen
dc.subjecthypothalamic-pituitary-adrenal axisen
dc.subjectanxiety-like behaviouren
dc.subjectelevated plus mazeen
dc.subjectraten
dc.titleHormonal and behavioural responses of paradoxical sleep-deprived rats to the elevated plus mazeen
dc.typeinfo:eu-repo/semantics/article
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