Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice

Página do item simplificado
dc.citation.issue3
dc.citation.volume77
dc.contributor.authorJunqueira Rocha, Viviane Costa
dc.contributor.authorde Aragao Franca, Luciana Souza
dc.contributor.authorde Araujo, Cintia Figueiredo
dc.contributor.authorNg, Ayling Martins
dc.contributor.authorde Andrade, Candace Machado
dc.contributor.authorAndrade, Andre Cronemberger [UNIFESP]
dc.contributor.authorSantos, Emanuelle de Souza
dc.contributor.authorBorges-Silva, Mariana da Cruz
dc.contributor.authorMacambira, Simone Garcia
dc.contributor.authorNoronha-Dutra, Alberto Augusto
dc.contributor.authorPontes-de-Carvalho, Lain Carlos
dc.coverageNew York
dc.date.accessioned2020-08-21T17:00:12Z
dc.date.available2020-08-21T17:00:12Z
dc.date.issued2016
dc.description.abstractDoxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice. C57BL/6 mice were treated twice with mito-T at low (5 mg/kg body weight) or high (20 mg/kg body weight) dose and once with DOX (24 mg/kg body weight) or saline (0.1 mL/20 g body weight) by means of intraperitoneal injections. The levels of malondialdehyde (MLDA), a marker of lipid peroxidation, and serum levels of creatine kinase were evaluated 48 h after the injection of DOX. DOX induced lipid peroxidation in heart mitochondria (p < 0.001), and DOX-treated mice receiving mito-T at low dose had levels of MLDA significantly lower than the mice that received only DOX (p < 0.01). Furthermore, administration of mito-T alone did not cause any significant changes from control values. Additionally, DOX-treated mice treated with mito-T at high dose showed decrease in serum levels of total CK compared to mice treated with DOX alone (p < 0.05). Our results indicate that mito-T protects mice against DOX-induced cardiotoxicity.en
dc.description.affiliationFundacao Oswaldo Cruz, Goncallo Moniz Res Ctr, Rua Waldemar Falcao 121, BR-40296710 Salvador, BA, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Imunol Celular & Bioquim Fungos & Protozoario, Sao Paulo, Brazil
dc.description.affiliationUCL, London, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Imunol Celular & Bioquim Fungos & Protozoario, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado da Bahia-FAPESB, State Government of Bahia, Brazil
dc.description.sponsorshipFundacao Oswaldo Cruz, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq, Ministry of Science and Technology, Brazil
dc.format.extent659-662
dc.identifierhttp://dx.doi.org/10.1007/s00280-015-2949-7
dc.identifier.citationCancer Chemotherapy And Pharmacology. New York, v. 77, n. 3, p. 659-662, 2016.
dc.identifier.doi10.1007/s00280-015-2949-7
dc.identifier.fileWOS000371246100023.pdf
dc.identifier.issn0344-5704
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57908
dc.identifier.wosWOS:000371246100023
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCancer Chemotherapy And Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDoxorubicinen
dc.subjectCardiotoxicityen
dc.subjectMitochondriaen
dc.subjectMito-TEMPOen
dc.titleProtective effects of mito-TEMPO against doxorubicin cardiotoxicity in miceen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000371246100023.pdf
Tamanho:
450.49 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos