ANGIOTENSIN (5-8) MODULATES NOCICEPTION AT the RAT PERIAQUEDUCTAL GRAY VIA the NO-sGC PATHWAY and AN ENDOGENOUS OPIOID

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dc.contributor.authorGuethe, L. M.
dc.contributor.authorPelegrini-da-Silva, A.
dc.contributor.authorBorelli, K. G.
dc.contributor.authorJuliano, M. A. [UNIFESP]
dc.contributor.authorPelosi, G. G.
dc.contributor.authorPesquero, J. B. [UNIFESP]
dc.contributor.authorSilva, C. L. M.
dc.contributor.authorCorrea, F. M. A.
dc.contributor.authorMurad, F.
dc.contributor.authorPrado, W. A.
dc.contributor.authorMartins, A. R.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Fed Triangulo Mineiro
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionGeorge Washington Univ
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2016-01-24T14:31:16Z
dc.date.available2016-01-24T14:31:16Z
dc.date.issued2013-02-12
dc.description.abstractAngiotensins (Angs) modulate blood pressure, hydro-electrolyte composition, and antinociception. Although Ang (5-8) has generally been considered to be inactive, we show here that Ang (5-8) was the smallest Ang to elicit dose-dependent responses and receptor-mediated antinociception in the rat ventrolateral periaqueductal gray matter (vlPAG). Ang (5-8) antinociception seems to be selective, because it did not alter blood pressure or act on vascular or intestinal smooth muscle cells. the non-selective Ang-receptor (Ang-R) antagonist saralasin blocked Ang (5-8) antinociception, but selective antagonists of Ang-R types I, II, IV, and Mas did not, suggesting that Ang (5-8) may act via an unknown receptor. Endopeptidase EP 24.11 and amastatin-sensitive aminopeptidase from the vlPAG catalyzed the synthesis (from Ang II or Ang III) and inactivation of Ang (5-8), respectively. Selective inhibitors of neuronal-nitric oxide (NO) synthase, soluble guanylyl cyclase (sGC) and a nonselective opioid receptor (opioid-R) inhibitor blocked Ang (5-8)-induced antinociception. in conclusion, Ang (5-8) is a new member of the Ang family that selectively and strongly modulates antinociception via NO-sGC and endogenous opioid in the vlPAG. (c) 2012 IBRO. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationFFCLRP Univ São Paulo, Dept Psychol, BR-14049901 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Inst Neurosci & Behav INeC, BR-14049901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Biol Sci, BR-38025015 Uberaba, MG, Brazil
dc.description.affiliationEscola Paulista Med UNIFESP, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, ICB, Cellular & Mol Pharmacol Res Program, BR-21941599 Rio de Janeiro, RJ, Brazil
dc.description.affiliationGeorge Washington Univ, Dept Biochem & Mol Biol, Washington, DC 20037 USA
dc.description.affiliationUniv Estadual Londrina, Dept Physiol Sci, Ctr Biol Sci, BR-86055900 Londrina, PR, Brazil
dc.description.affiliationUnifespEscola Paulista Med UNIFESP, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 306008/2009-2
dc.description.sponsorshipIDCNPq: 561151/2010-5
dc.description.sponsorshipIDCNPq: 472474/2010-3
dc.description.sponsorshipIDCNPq: 476394/2012-0
dc.description.sponsorshipIDCNPq: 159841/2010-0
dc.description.sponsorshipIDFAPESP: 2008/06676-8
dc.format.extent315-327
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2012.11.048
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 231, p. 315-327, 2013.
dc.identifier.doi10.1016/j.neuroscience.2012.11.048
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35974
dc.identifier.wosWOS:000314744200029
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectangiotensin (5-8)en
dc.subjectantinociceptionen
dc.subjectpainen
dc.subjectperiaqueductal gray matteren
dc.subjectincision allodynia modelen
dc.subjecttail-flick testen
dc.titleANGIOTENSIN (5-8) MODULATES NOCICEPTION AT the RAT PERIAQUEDUCTAL GRAY VIA the NO-sGC PATHWAY and AN ENDOGENOUS OPIOIDen
dc.typeinfo:eu-repo/semantics/article
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