Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain

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dc.contributor.authorPaccola, Carina Cicconi
dc.contributor.authorGutierrez, Vanessa Pacciari
dc.contributor.authorLongo, Ingrid
dc.contributor.authorJuliano, Luiz [UNIFESP]
dc.contributor.authorJuliano, Maria Aparecida [UNIFESP]
dc.contributor.authorGiorgi, Renata
dc.contributor.institutionButantan Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:44Z
dc.date.available2016-01-24T13:51:44Z
dc.date.issued2008-10-01
dc.description.abstractThe synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models. in this study, the effect of mS100A9p was investigated on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in rats. Hyperalgesia, allodynia, and spontaneous pain were assessed to evaluate nociception. These three signs were detected as early as 2 days after sciatic nerve constriction and lasted for over 14 days after CCI. Rats were treated with different doses of mS100A9p by intraplantar, oral, or intrathecal routes on day 14 after CCI, and nociception was evaluated 1 h later. These three routes of administration blocked hyperalgesia, allodynia and spontaneous pain. the duration of the effect of mS100A9p depends on the route used and phenomenon analyzed. Moreover, intraplantar injection of mS100A9p in the contralateral paw inhibited the hyperalgesia on day 14 days after CCI the results obtained herein demonstrate the antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain, suggesting a potential therapeutic use for it in persistent pain syndromes, assuming that tolerance does not develop to mS100A9p. (C) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationButantan Inst, Lab Pathophysiol, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Pharmacol, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Pharmacol, Dept Biophys, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundacao Butantan
dc.format.extent1806-1814
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2008.05.023
dc.identifier.citationPeptides. New York: Elsevier B.V., v. 29, n. 10, p. 1806-1814, 2008.
dc.identifier.doi10.1016/j.peptides.2008.05.023
dc.identifier.issn0196-9781
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30946
dc.identifier.wosWOS:000260284100022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPeptides
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectNeuropathic painen
dc.subjectS100A9en
dc.subjectAntinociceptionen
dc.subjectSciatic nerveen
dc.subjectChronic constriction injuryen
dc.titleAntinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic painen
dc.typeinfo:eu-repo/semantics/article
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