Mesenchymal stem cells and chronic renal artery stenosis

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dc.contributor.authorOliveira-Sales, Elizabeth Barbosa de [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-07-26T17:30:30Z
dc.date.available2018-07-26T17:30:30Z
dc.date.issued2016
dc.description.abstractRenal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. Considering the limited number of strategies that effectively control renovascular hypertension and restore renal function, we propose that cell therapy may be a promising option based on the regenerative and immunosuppressive properties of stem cells. This review addresses the effects of mesenchymal stem cells (MSC) in an experimental animal model of renovascular hypertension known as 2 kidney-1 clip (2K-1C). Significant benefits of MSC treatment have been observed on blood pressure and renal structure of the stenotic kidney. The mechanisms involved are discussed.en
dc.description.affiliationNephrology Division, Federal University of São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespRenal Division, Federal University of São Paulo, Rua Pedro de Toledo, 781 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipFundação Oswaldo Ramos (FOR)
dc.format.extentF6-F9
dc.identifierhttps://dx.doi.org/10.1152/ajprenal.00341.2015
dc.identifier.citationAmerican Journal Of Physiology-Renal Physiology. Bethesda, v. 310, n. 1, p. F6-F9, 2016.
dc.identifier.doi10.1152/ajprenal.00341.2015
dc.identifier.issn1931-857X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/46088
dc.identifier.wosWOS:000366593500002
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal Of Physiology-Renal Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal sympathetic nerveen
dc.subjectRenin-angiotensin systemen
dc.subjectRenovascular hypertensionen
dc.subjectCell therapyen
dc.subjectRenal ischemiaExperimental Renovascular Diseaseen
dc.subjectEndothelial Progenitor Cellsen
dc.subjectAngiotensin-Iien
dc.subjectOxidative Stressen
dc.subjectNervous-Systemen
dc.subjectRat Modelen
dc.subjectHypertensionen
dc.subjectInjuryen
dc.subjectMechanismsen
dc.subjectSenescenceen
dc.titleMesenchymal stem cells and chronic renal artery stenosisen
dc.typeinfo:eu-repo/semantics/review
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