Amphetamine-induced rapid-onset sensitization: Role of novelty, conditioning and behavioral parameters

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dc.contributor.authorNascimento Alvarez, J. do
dc.contributor.authorFukushiro, D. F.
dc.contributor.authorObara Tatsu, J. A.
dc.contributor.authorPereira de Carvalho, E.
dc.contributor.authorCastro Gandolfi, A. C. de
dc.contributor.authorTsuchiya, J. B.
dc.contributor.authorCarrara-Nascimento, P. F.
dc.contributor.authorLima, M. L.
dc.contributor.authorGentil Bellot, R.
dc.contributor.authorFrussa-Filho, R.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Metodista São Paulo
dc.date.accessioned2016-01-24T12:41:04Z
dc.date.available2016-01-24T12:41:04Z
dc.date.issued2006-04-01
dc.description.abstractBackground: Environmental factors may modulate sensitization to the locomotor-activating effects of psychostimulants. in addition, some parameters of locomotor activity seem to be more sensitive to detect cocaine-induced behavioral sensitization. We examined how novelty and conditioning can modulate a previously described rapid-onset type of behavioral sensitization to amphetamine (AMP) in mice, using total, peripheral and central open-field locomotion frequencies as experimental parameters.Methods: in the first experiment, mice received an ip injection of saline (SAL) or 5.0 mg/kg AMP paired or not with the open-field or in their home-cages. Four hours later, all the animals received an ip SAL challenge injection and, 15 min later, were observed in the open-field for quantification of total, peripheral and central locomotion frequencies. the second experiment had a similar protocol, except that mice received a challenge injection of 1.5 mg/kg AMP.Results: the priming AMP injection significantly increased all the parameters of locomotion of SAL-challenged mice firstly exposed to or previously paired (but not impaired) with the open-field. AMP priming injection enhanced total and peripheral locomotion of all AMP-challenged mice but only increased central locomotion of mice submitted to novelty or environmental conditioning.Conclusion: Our results showed: 1) the development of an AMP-induced rapid-onset sensitization to novelty and rapid-onset environmental conditioning in mice, 2) the potentiation of the AMP-induced rapid-onset sensitization to an AMP challenge injection by novelty and environmental conditioning and 3) the importance of measuring different locomotor activity parameters in behavioral sensitization experiments. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUNIFESP, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Metodista São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent500-507
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2006.03.010
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 83, n. 4, p. 500-507, 2006.
dc.identifier.doi10.1016/j.pbb.2006.03.010
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28822
dc.identifier.wosWOS:000238497300003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectnoveltyen
dc.subjectenvironmental conditioningen
dc.subjectamphetamineen
dc.subjectrapid-onset behavioral sensitizationen
dc.subjectlocomotion paramatersen
dc.subjectmiceen
dc.titleAmphetamine-induced rapid-onset sensitization: Role of novelty, conditioning and behavioral parametersen
dc.typeinfo:eu-repo/semantics/article
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