Chromatin and nuclear organization in Trypanosoma cruzi

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dc.contributor.authorElias, Maria Carolina
dc.contributor.authorNardelli, Sheila Cristina [UNIFESP]
dc.contributor.authorSchenkman, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Butantan
dc.date.accessioned2016-01-24T13:58:49Z
dc.date.available2016-01-24T13:58:49Z
dc.date.issued2009-10-01
dc.description.abstractA total of 100 years have passed since the discovery of the protozoan Trypanosoma cruzi, the etiologic agent of Chagas' disease. Since its discovery, the molecular and cellular biology of this early divergent eukaryote, as well as its interactions with the mammalian and insect hosts, has progressed substantially. It is now clear that this parasite presents unique mechanisms controlling gene expression, DNA replication, cell cycle and differentiation, generating several morphological forms that are adopted to survive in different hosts, in recent years, the relationship between the chromatin structure and nuclear organization with the unusual transcription, splicing, DNA replication and DNA repair mechanisms have been investigated in T. cruzi. This article reviews the relevant aspects of these mechanisms in relation to chromatin and nuclear organization.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationInst Butantan, Parasitol Lab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1065-1074
dc.identifierhttp://dx.doi.org/10.2217/FMB.09.74
dc.identifier.citationFuture Microbiology. London: Future Medicine Ltd, v. 4, n. 8, p. 1065-1074, 2009.
dc.identifier.doi10.2217/FMB.09.74
dc.identifier.issn1746-0913
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31882
dc.identifier.wosWOS:000271143100015
dc.language.isoeng
dc.publisherFuture Medicine Ltd
dc.relation.ispartofFuture Microbiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectcell cycleen
dc.subjectchromatinen
dc.subjectcyclinen
dc.subjectDNA repairen
dc.subjecthistonesen
dc.subjectnucleusen
dc.subjectreplicationen
dc.subjecttranscriptionen
dc.subjectTrypamosoma cruzien
dc.titleChromatin and nuclear organization in Trypanosoma cruzien
dc.typeinfo:eu-repo/semantics/article
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