Does pediatric post-traumatic stress disorder alter the brain? Systematic review and meta-analysis of structural and functional magnetic resonance imaging studies

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dc.citation.issue3
dc.citation.volume71
dc.contributor.authorMilani, Ana Carolina C. [UNIFESP]
dc.contributor.authorHoffmann, Elis V. [UNIFESP]
dc.contributor.authorFossaluza, Victor
dc.contributor.authorJackowski, Andrea P. [UNIFESP]
dc.contributor.authorMello, Marcelo F. [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-17T14:02:50Z
dc.date.available2020-07-17T14:02:50Z
dc.date.issued2017
dc.description.abstractSeveral studies have recently demonstrated that the volumes of specific brain regions are reduced in children and adolescents with post-traumatic stress disorder (PTSD) compared with those of healthy controls. Our study investigated the potential association between early traumatic experiences and altered brain regions and functions. We conducted a systematic review of the scientific literature regarding functional magnetic resonance imaging and a meta-analysis of structural magnetic resonance imaging studies that investigated cerebral region volumes in pediatric patients with PTSD. We searched for articles from 2000 to 2014 in the PsycINFO, PubMed, Medline, Lilacs, and ISI (Web of Knowledge) databases. All data regarding the amygdala, hippocampus, corpus callosum, brain, and intracranial volumes that fit the inclusion criteria were extracted and combined in a meta-analysis that assessed differences between groups. The meta-analysis found reduced total corpus callosum areas and reduced total cerebral and intracranial volumes in the patients with PTSD. The total hippocampus (left and right hippocampus) and gray matter volumes of the amygdala and frontal lobe were also reduced, but these differences were not significant. The functional studies revealed differences in brain region activation in response to stimuli in the post-traumatic stress symptoms/PTSD group. Our results confirmed that the pediatric patients with PTSD exhibited structural and functional brain abnormalities and that some of the abnormalities occurred in different brain regions than those observed in adults.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Math & Stat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipIDFAPESP: 2010/09104-5
dc.format.extent154-169
dc.identifierhttp://dx.doi.org/10.1111/pcn.12473
dc.identifier.citationPsychiatry And Clinical Neurosciences. Hoboken, v. 71, n. 3, p. 154-169, 2017.
dc.identifier.doi10.1111/pcn.12473
dc.identifier.issn1323-1316
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55056
dc.identifier.wosWOS:000395433100002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPsychiatry And Clinical Neurosciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadolescenten
dc.subjectanxiety disordersen
dc.subjectchilden
dc.subjectfunctional neuroimagingen
dc.subjectmagnetic resonance imagingen
dc.titleDoes pediatric post-traumatic stress disorder alter the brain? Systematic review and meta-analysis of structural and functional magnetic resonance imaging studiesen
dc.typeinfo:eu-repo/semantics/article
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