Association between ABCB1 Immunohistochemical Expression and Overall Survival in Gastric Cancer Patients

Página do item simplificado
dc.contributor.authorOliveira, Juliana de [UNIFESP]
dc.contributor.authorFelipe, Aledson Vitor [UNIFESP]
dc.contributor.authorArtigiani Neto, Ricardo [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorSilva, Marcelo de Souza [UNIFESP]
dc.contributor.authorForones, Nora Manoukian [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:01Z
dc.date.available2016-01-24T14:35:01Z
dc.date.issued2014-01-01
dc.description.abstractGastric cancer (GC) is one of the most common malignancies worldwide. the ABCB1 protein, a member of the ATP-binding cassette (ABC) transporter family, encoded by the ABCB1 gene, considerably influences the distribution of drugs across cell membranes as well as multidrug resistance (MDR) of antineoplastic drugs. in contrast to the extensive knowledge on the pharmacological action of ABCB1 protein, the correlation between the clinical-pathological data and ABCB1 protein expression in patients with GC remains unclear. the aim was to investigate association between ABCB1 expression and overall survival in GC patients. Human tumor fragments from 57 GC patients were examined by immunohistochemistry assay. We observed lower survival rate of patients with GC who were positive for ABCB1 expression (p=0.030). Based on these observations, we conclude that GC patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, Dept Med, UNIFESP, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Pathol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, Dept Med, UNIFESP, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Pathol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 10.19715-1
dc.format.extent6935-6938
dc.identifierhttps://dx.doi.org/10.7314/APJCP.2014.15.16.6935
dc.identifier.citationAsian Pacific Journal of Cancer Prevention. Gyeonggi-do: Asian Pacific Organization Cancer Prevention, v. 15, n. 16, p. 6935-6938, 2014.
dc.identifier.doi10.7314/APJCP.2014.15.16.6935
dc.identifier.fileWOS000343832900078.pdf
dc.identifier.issn1513-7368
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37204
dc.identifier.wosWOS:000343832900078
dc.language.isoeng
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectABCB1en
dc.subjectImmunohistochemistryen
dc.subjectGastric canceren
dc.subjectSurvivalen
dc.titleAssociation between ABCB1 Immunohistochemical Expression and Overall Survival in Gastric Cancer Patientsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000343832900078.pdf
Tamanho:
654.4 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos