MAPK7 and MAP2K4 as prognostic markers in osteosarcoma

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dc.contributor.authorTesser-Gamba, Francine [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.authorSeixas Alves, Maria Teresa de [UNIFESP]
dc.contributor.authorGarcia Filho, Reynaldo Jesus [UNIFESP]
dc.contributor.authorJuliano, Yara
dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Santo Amaro
dc.date.accessioned2016-01-24T14:27:26Z
dc.date.available2016-01-24T14:27:26Z
dc.date.issued2012-07-01
dc.description.abstractOsteosarcoma is a class of cancer originating from the bone, affecting mainly children and young adults. Cytogenetic studies showed the presence of rearrangements and recurrent gains in specific chromosomal regions, indicating the possible involvement of genes located in these regions during the pathogenesis of osteosarcoma. These studies investigated expression of 10 genes located in the chromosomal region involved in abnormalities in osteosarcoma, 1p36, 17p, and chromosome 19. the purpose of this study was to investigate the expression profile of genes located in regions involved in chromosomal rearrangements in osteosarcoma. We used quantitative real-time polymerase chain reaction to investigate the expression of 10 genes located in 1p36.3 (MTHFR, ERRFI1, FGR, E2F2), 17p (MAPK7, MAP2K4), and chromosome 19 (BBC3, FOSB, JUND, and BRAS), in 70 samples taken from 30 patients (30 prechemotherapy, 30 postchemotherapy, and 10 metastases specimens) and 10 healthy bones as a control sample. the most interesting results showed a strong association between the expression levels of MAPK7 and MAP2K4 genes and clinical parameters of osteosarcoma. Overexpression of these genes was significantly associated to a poor response to treatment (P = .0001 and P = .0049, respectively), tumor progression, and worse overall survival (P = .0052 and P = .0085, respectively), suggesting that MAPK7 and MAP2K4 could play an important role in osteosarcoma tumorigenesis. Thus, these genes could be good markers in assessing response to treatment and development of osteosarcoma. (C) 2012 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Pediat Oncol Inst, Grp Apoio Ao Adolescente & Crianca Com Canc, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Santo Amaro, Dept Publ Hlth, BR-04829300 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Pediat Oncol Inst, Grp Apoio Ao Adolescente & Crianca Com Canc, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipGrupo de Apoio ao Adolescente e a Crianca corn Cancer/Federal University of São Paulo (São Paulo, Brazil)
dc.description.sponsorshipIDFAPESP: 07/53869-3
dc.description.sponsorshipIDFAPESP: 07/02693-2
dc.format.extent994-1002
dc.identifierhttp://dx.doi.org/10.1016/j.humpath.2011.08.003
dc.identifier.citationHuman Pathology. Philadelphia: W B Saunders Co-Elsevier Inc, v. 43, n. 7, p. 994-1002, 2012.
dc.identifier.doi10.1016/j.humpath.2011.08.003
dc.identifier.issn0046-8177
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35059
dc.identifier.wosWOS:000305775200005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHuman Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectOsteosarcoma (OS)en
dc.subjectGene expressionen
dc.subjectOS markersen
dc.subjectMAPK7en
dc.subjectMAP2K4en
dc.titleMAPK7 and MAP2K4 as prognostic markers in osteosarcomaen
dc.typeinfo:eu-repo/semantics/article
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