Resistance trends of Acinetobacter spp. in Latin America and characterization of international dissemination of multi-drug resistant strains: five-year report of the SENTRY Antimicrobial Surveillance Program

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dc.contributor.authorTognim, Maria Cristina Bronharo [UNIFESP]
dc.contributor.authorAndrade, Soraya Sgambatti [UNIFESP]
dc.contributor.authorSilbert, Suzane [UNIFESP]
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorJones, Ronald N.
dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionJones Grp
dc.date.accessioned2016-01-24T12:37:20Z
dc.date.available2016-01-24T12:37:20Z
dc.date.issued2004-09-01
dc.description.abstractObjectives: To analyze the antimicrobial susceptibility of Acinetobacter spp. isolates collected from Latin American medical centers as part of the SENTRY Antimicrobial Surveillance Program and also to evaluate the dissemination of mutti-drug resistant Acinetobacter spp. strains in the region.Methods: A total of 826 isolates of Acinetobacter spp. from multiple infection sites were collected from January 1997 to December 2001 in ten medical centers and susceptibility tested to >25 selected agents by broth microdilution. Multi-drug resistant Acinetobacter spp. isolates were molecular typed.Results: Resistance rates to carbapenems varied significantly among countries. A continued annual increase occurred in the Argentinean medical centers. in contrast, carbapenem resistance was rare in Chilean centers, and decreased significantly in the Brazilian institutions. Acinetobacter spp. isolates recovered from lower respiratory tract and bloodstream infections were associated with lower antimicrobial susceptibility rates. Resistance rates to imipenem were higher among isolates collected from intensive care units (13.5%) than among isolates from other units. A major ribogroup pattern (521-1) was detected among eight Acinetobocter spp. strains isolated from three distinct Latin American countries.Conclusions: This study found that antimicrobial resistance is still a major issue among Acinetobacter spp. isolates collected from some Latin American countries. the dissemination of a major bacterial cluster in different regions reinforces the importance of longitudinal surveillance programs, such as SENTRY, as valuable tools for monitoring antimicrobial susceptibility rates and guiding local interventions. (C) 2004 International Society for Infectious Diseases. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Lab Especial Microbiol Clin, Disciplina Doencas Infecciosas & Parasitarias, BR-04025010 São Paulo, Brazil
dc.description.affiliationUniv Estadual Maringa, Dept Anal Clin, Maringa, Parana, Brazil
dc.description.affiliationJones Grp, JMI Labs, N Liberty, IA USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Especial Microbiol Clin, Disciplina Doencas Infecciosas & Parasitarias, BR-04025010 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent284-291
dc.identifierhttp://dx.doi.org/10.1016/j.ijid.2003.11.009
dc.identifier.citationInternational Journal of Infectious Diseases. Oxford: Elsevier B.V., v. 8, n. 5, p. 284-291, 2004.
dc.identifier.doi10.1016/j.ijid.2003.11.009
dc.identifier.fileWOS000223966900009.pdf
dc.identifier.issn1201-9712
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27897
dc.identifier.wosWOS:000223966900009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAcinetobacteren
dc.subjectantimicrobial resistanceen
dc.subjectcarbapenem resistanceen
dc.subjectLatin Americaen
dc.subjectpolymyxinen
dc.subjectSENTRYen
dc.titleResistance trends of Acinetobacter spp. in Latin America and characterization of international dissemination of multi-drug resistant strains: five-year report of the SENTRY Antimicrobial Surveillance Programen
dc.typeinfo:eu-repo/semantics/article
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