What do Cochrane systematic reviews say about the clinical effectiveness of screening and diagnostic tests for cancer?

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dc.citation.issue4]
dc.citation.volume135]
dc.contributor.authorPereira Bueno, Andre Tito [UNIFESP]
dc.contributor.authorCapelasso, Vladimir Lisboa [UNIFESP]
dc.contributor.authorPacheco, Rafael Leite [UNIFESP]
dc.contributor.authorCruz Latorraca, Carolina de Oliveira [UNIFESP]
dc.contributor.authorde Castria, Tiago Biachi
dc.contributor.authorPachito, Daniela Vianna [UNIFESP]
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-06-26T16:30:26Z
dc.date.available2020-06-26T16:30:26Z
dc.date.issued2017
dc.description.abstractCONTEXT AND OBJECTIVE: The purpose of screening tests for cancer is to detect it at an early stage in order to increase the chances of treatment. However, their unrestrained use may lead to unnecessary examinations, overdiagnosis and higher costs. It is thus necessary to evaluate their clinical effects in terms of benefits and harm. DESIGN AND SETTING: Review of Cochrane systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo. METHODS: Cochrane reviews on the clinical effectiveness of cancer screening procedures were included. Study titles and abstracts were independently assessed by two authors. Conflicts were resolved by another two authors. Findings were summarized and discussed. RESULTS: Seventeen reviews were selected: fifteen on screening for specific cancers (bladder, breast, colorectal, hepatic, lung, nasopharyngeal, esophageal, oral, prostate, testicular and uterine) and two others on cancer in general. The quality of evidence of the findings varied among the reviews. Only two reviews resulted in high-quality evidence: screening using low-dose computed tomography scans for high-risk individuals seems to reduce lung cancer mortalityen
dc.description.abstractand screening using flexible sigmoidoscopy and fecal occult blood tests seems to reduce colorectal cancer mortality. CONCLUSION: The evidence found through Cochrane reviews did not support most of the commonly used screening tests for cancer. It is recommended that patients should be informed of the possibilities of false positives and false negatives before they undergo the tests. Further studies to fully assess the effectiveness of cancer screening tests and adverse outcomes are required.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, SP, Brazil
dc.description.affiliationCochrane Brazil, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo USP, Fac Med, Inst Canc Estado Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Sirio Libanes, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Discipline Evidence Based Med, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Discipline Evidence Based Med, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent401-410
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2017.0171110717]
dc.identifier.citationSao Paulo Medical Journal. Sao Paulo, v. 135, n. 4, p. 401-410, 2017.
dc.identifier.doi10.1590/1516-3180.2017.0171110717
dc.identifier.fileS1516-31802017000400401.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802017000400401
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53537
dc.identifier.wosWOS:000407814900013
dc.language.isoeng
dc.publisherAssociacao Paulista Medicina
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiagnosisen
dc.subjectEarly detection of canceren
dc.subjectTreatment outcomeen
dc.subjectReview [publication type]en
dc.subjectEvidence-based practiceen
dc.titleWhat do Cochrane systematic reviews say about the clinical effectiveness of screening and diagnostic tests for cancer?en
dc.typeinfo:eu-repo/semantics/article
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