Brazilian data of renal cell carcinoma in a public university hospital

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dc.contributor.authorAguiar Junior, Pedro [UNIFESP]
dc.contributor.authorPadua, Tiago Costa [UNIFESP]
dc.contributor.authorGuimaraes, Daiane Pereira [UNIFESP]
dc.date.accessioned2019-01-21T10:30:05Z
dc.date.available2019-01-21T10:30:05Z
dc.date.issued2016
dc.description.abstractPurpose: Among renal malignancies, renal cell carcinoma (RCC) accounts for 85% of cases. Stage is a relevant prognostic factoren
dc.description.abstract5-year survival ranges from 81% to 8% according to the stage of disease. The treatment is based on surgery and molecularly targeted therapy has emerged as a choice for metastatic disease. Materials and Methods: Retrospective study by reviewing the medical records of patients with RCC treated in the last 10 years at UNIFESP. The primary end point of this trial was to evaluate the overall survival (OS) of the patients. The secondary end point was to evaluate the progression-free survival (PFS) after nephrectomy. Results: 118 patients with RCC were included. The mean age was 58.3 years, 61.9% menen
dc.description.abstractnephrectomy was performed in 90.7%, clear cell was the histology in 85.6%, 44 patients were classified as stage IV at diagnosis. Among these, 34 had already distant metastasis. 29 patients were treated with sunitinib. The median OS among all patients was 55.8 months. The median PFS after nephrectomy was 79.1 months. Sarcomatoid differentiation HR29.74 (95% CI, 4.31-205.26), clinical stage IV HR1.94 (95% CI, 1.37-2.75) and nephrectomy HR0.32 (95% CI, 0.15-0.67) were OS prognostic factors. Sunitinib had clinical activity. Conclusions: Patients treated in our hospital achieved median OS compatible with literature. Nevertheless, this study has shown a high number of patients with advanced disease. For patients with advanced disease, treatment with sunitinib achieved median OS of 28.7 months, consistent with the literature.en
dc.description.affiliationDepartamento de Oncologia, Unifesp, Rua Pedro de Toledo 377, BR-04039031 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartamento de Oncologia, Unifesp, Rua Pedro de Toledo 377, BR-04039031 Sao Paulo, SP, Brazil.
dc.description.sourceWeb of Science
dc.format.extent29-36
dc.identifierhttp://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0452
dc.identifier.citationInternational Braz J Urol. Rio de janeiro, v. 42, n. 1, p. 29-36, 2016.
dc.identifier.doi10.1590/S1677-5538.IBJU.2014.0452
dc.identifier.fileS1677-55382016000100029.pdf
dc.identifier.issn1677-5538
dc.identifier.scieloS1677-55382016000100029
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49573
dc.identifier.wosWOS:000372333400007
dc.language.isoeng
dc.publisherBrazilian soc urol
dc.relation.ispartofInternational Braz J Urol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal Carcinomaen
dc.subjectNephrectomyen
dc.subjectSunitiniben
dc.subjectSurvivalTherapyen
dc.subjectImpacten
dc.subjectSunitiniben
dc.subjectSurvivalen
dc.titleBrazilian data of renal cell carcinoma in a public university hospitalen
dc.typeinfo:eu-repo/semantics/article
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