Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis

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dc.contributor.authorOkamoto, Oswaldo Keith [UNIFESP]
dc.contributor.authorPerez, Jose Fernando [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:33Z
dc.date.available2016-01-24T13:51:33Z
dc.date.issued2008-07-01
dc.description.abstractThis review discusses some of the impacts that biotechnology, genomics and nanotechnology convergence should have on future cancer management, in particular, the development of innovative diagnostic and therapeutic approaches based on monoclonal antibodies (mAbs) and cancer stem cells. Emergent therapeutic strategies in cancer have been focusing on the use of mAbs to stimulate an immune response against tumors, to block signaling pathways, or to refine delivery of cytotoxic agents. Now that cancer stem cells are being identified and characterized in different tumor types, their relevance to cancer physiopathology is becoming evident, making them natural targets for mAb development. Cancer stem cells are postulated to be responsible for tumor development, metastasis and relapse after conventional therapies. Therefore, mAbs targeting specific antigens and related pathways altered in cancer stem cells should facilitate earlier diagnosis through molecular imaging techniques and more efficient destruction of tumor initiating cells, thus improving clinical outcome.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent387-393
dc.identifierhttp://dx.doi.org/10.1586/14737159.8.4.387
dc.identifier.citationExpert Review of Molecular Diagnostics. London: Expert Reviews, v. 8, n. 4, p. 387-393, 2008.
dc.identifier.doi10.1586/14737159.8.4.387
dc.identifier.issn1473-7159
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30796
dc.identifier.wosWOS:000257765700005
dc.language.isoeng
dc.publisherExpert Reviews
dc.relation.ispartofExpert Review of Molecular Diagnostics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbiotechnologyen
dc.subjectcanceren
dc.subjectcancer stem cellen
dc.subjectmagnetohyperthermiaen
dc.subjectmolecular imagingen
dc.subjectmonoclonal antibodyen
dc.subjectnanobiotechnologyen
dc.subjectpharmacogenomicsen
dc.subjectsiRNAen
dc.subjecttarget therapyen
dc.titleTargeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosisen
dc.typeinfo:eu-repo/semantics/article
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