ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION: A Natural History Study From the Pan American Collaborative Retina Study Group

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dc.citation.issue10
dc.citation.volume36
dc.contributor.authorWu, Lihteh
dc.contributor.authorZas, Marcelo
dc.contributor.authorBerrocal, Maria H.
dc.contributor.authorArevalo, J. Fernando
dc.contributor.authorFigueroa, Marta
dc.contributor.authorRodriguez, Francisco
dc.contributor.authorSerrano, Martin
dc.contributor.authorGraue, Federico
dc.contributor.authorAlezzandrini, Arturo
dc.contributor.authorGallego-Pinazo, Roberto
dc.contributor.authorRoca, Jose A.
dc.contributor.authorIglicki, Matias
dc.contributor.authorDalma-Weishauz, Jose
dc.contributor.authorKozak, Igor
dc.contributor.authorCollado, Alberto
dc.contributor.authorBadal, Josep
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.contributor.authorSalcedo-Villanueva, Guillermo
dc.contributor.authorQuiroz-Mercado, Hugo
dc.contributor.authorFromow-Guerra, Jans
dc.contributor.authorLozano-Rechy, David
dc.contributor.authorAvila, Marcos
dc.contributor.authorChhablani, Jay
dc.coveragePhiladelphia
dc.date.accessioned2020-07-31T12:47:40Z
dc.date.available2020-07-31T12:47:40Z
dc.date.issued2016
dc.description.abstractPurpose:To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).Methods:Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.Results:There were 168 patients (51 men) with a mean age of 68.8 10.7 years. Patients were followed for a mean of 22.7 +/- 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 +/- 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 +/- 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 +/- 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 +/- 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 +/- 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45en
dc.description.abstractP = 0.0372), and the mean central macular thickness improved from 350 +/- 132 m to 323 +/- 121 m.Conclusion:Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 +/- 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.en
dc.description.affiliationMacula Vitreous & Retina Associates Costa Rica, San Jose, Costa Rica
dc.description.affiliationUniv Buenos Aires, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Puerto Rico, San Juan, PR 00936 USA
dc.description.affiliationKing Khalid Eye Specialist Hosp, Riyadh, Saudi Arabia
dc.description.affiliationJohns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA
dc.description.affiliationRamon & Cajal Univ Hosp, Retina Dept, Madrid, Spain
dc.description.affiliationVISSUM Madrid, Madrid, Spain
dc.description.affiliationRosario Univ, Natl Ophthalmol Fdn, Bogota, Colombia
dc.description.affiliationCtr Caracas Ophthalmol Clin, Caracas, Venezuela
dc.description.affiliationConde Valenciana Fdn, Mexico City, DF, Mexico
dc.description.affiliationOFTALMOS Univ Buenos Aires, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Valencia, La Fe Hosp, Valencia, Spain
dc.description.affiliationRicardo Palma Clin, Lima, Peru
dc.description.affiliationAssoc Blindness Prevent Mexico, Mexico City, DF, Mexico
dc.description.affiliationMoises Broggi Hosp, Dept Ophthalmol, Retina & Vitreous Unit, Barcelona, Spain
dc.description.affiliationUniv Fed Sao Paulo, Vision Inst, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUniv Colorado, Sch Med, Denver, CO 80309 USA
dc.description.affiliationUniv Fed Goias, Dept Ophthalmol, Goiania, Go, Brazil
dc.description.affiliationLV Prasad Eye Inst, Hyderabad, Andhra Pradesh, India
dc.description.affiliationUnifespDepartment of Ophthalmology, Vision Institute, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1913-1918
dc.identifierhttp://dx.doi.org/10.1097/IAE.0000000000001015
dc.identifier.citationRetina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 36, n. 10, p. 1913-1918, 2016.
dc.identifier.doi10.1097/IAE.0000000000001015
dc.identifier.issn0275-004X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56988
dc.identifier.wosWOS:000385998600026
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofRetina-The Journal Of Retinal And Vitreous Diseases
dc.rightsAcesso restrito
dc.subjectvitreomacular tractionen
dc.subjectmacular holeen
dc.subjectvitrectomyen
dc.subjectocriplasminen
dc.titleANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION: A Natural History Study From the Pan American Collaborative Retina Study Groupen
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