Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa

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dc.contributor.authorMarra, Alexandre R.
dc.contributor.authorBar, Katharine
dc.contributor.authorBearman, Gonzalo M. L.
dc.contributor.authorWenzel, Richard P.
dc.contributor.authorEdmond, Michael B.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionVirginia Commonwealth Univ
dc.date.accessioned2016-01-24T12:41:18Z
dc.date.available2016-01-24T12:41:18Z
dc.date.issued2006-07-01
dc.description.abstractObjectives: To evaluate relationships between the inflammatory response, clinical. course, and outcome of nosocomial. BSI due to Pseudomonas aeruginosa.Methods: We performed a historical cohort study on 77 adults with P. aeruginosa (Pa) nBSI to define the associated systemic inflammatory response syndrome (SIRS). We examined SIRS scores 2 days prior through 14 days after the first positive blood culture. Imipenem resistant-IRPa (n=20) and susceptible infections-ISPa (n=57) were compared. Variables significant in univariate analysis were entered into a logistic regression model.Results: Seventy-four percent of BSI were ISPa and 26.0% by IRPa. Septic shock occurred in 39.0%. Crude mortatity was 48.1%. There was no difference in APACHE II (AP2) scores on days -2, -1 and 0 between the ISPa and IRPa groups. Multivariate analysis revealed that AP2 >= 20 at BSI onset (P<0.001) and hematologic failure (P= 0.001) independently predicted death.Conclusions: in patients with P. aeruginosa nBSI, the incidence of septic shock and organ failure is high; patients with IRPa BSI are not more acutely M prior to infection than those with ISPa BSI and outcome is not significantly different; AP2 20 at BSI onset and the development of hematologic failure are independent predictors of death. (C) 2005 the British Infection Society. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, HSP, EPM, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, HSP, EPM, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent30-35
dc.identifierhttp://dx.doi.org/10.1016/j.jinf.2005.08.032
dc.identifier.citationJournal of Infection. London: W B Saunders Co Ltd, v. 53, n. 1, p. 30-35, 2006.
dc.identifier.doi10.1016/j.jinf.2005.08.032
dc.identifier.issn0163-4453
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29005
dc.identifier.wosWOS:000239256200007
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofJournal of Infection
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPseudomonas aeruginosaen
dc.subjectsystemic inflammatory responseen
dc.subjectbloodstream infectionen
dc.subjectimipenem resistanceen
dc.titleSystemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosaen
dc.typeinfo:eu-repo/semantics/article
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