Chronic Antioxidant Treatment Improves Arterial Renovascular Hypertension and Oxidative Stress Markers in the Kidney in Wistar Rats
| dc.contributor.author | Nishi, Erika Emy [UNIFESP] | |
| dc.contributor.author | Oliveira-Sales, Elizabeth Barbosa [UNIFESP] | |
| dc.contributor.author | Bergamaschi, Cassia T. [UNIFESP] | |
| dc.contributor.author | Cesar Oliveira, Thais Galvao [UNIFESP] | |
| dc.contributor.author | Boim, Mirian A. [UNIFESP] | |
| dc.contributor.author | Campos, Ruy R. [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T13:59:39Z | |
| dc.date.available | 2016-01-24T13:59:39Z | |
| dc.date.issued | 2010-05-01 | |
| dc.description.abstract | BACKGROUNDSympathetic vasomotor hyperactivity and baroreflex dysfunction are involved in the development and maintenance of renovascular arterial hypertension. We hypothesized that angiotensin (Ang) II-dependent oxidative stress contributes to the pathophysiology of the two-kidney, one-clip (2K-1C) model.METHODSThe mean arterial pressure (MAP), baroreflex, and renal sympathetic nerve activity (rSNA) were evaluated after chronic administration of an antioxidant, vitamin C (vitC 150 mg/kg/day) in male Wistar 2K-1C rats. Additionally, the mRNA levels of Ang II subtype 1 receptor (AT(1)R), NAD(P)H oxidase subunits (p47phox and gp91phox), and major antioxidant enzymes were evaluated in the renal cortex.RESULTSAfter vitC treatment, the MAP (170 +/- 4 vs. 133 +/- 6 mm Hg; P < 0.05) and rSNA (161 +/- 5 vs. 118 +/- 12 spikes/s; P < 0.05) were significantly reduced only in the 2K-1C group. VitC improved the baroreflex control of heart rate (HR) and rSNA. the expression of AT(1)R, p47phox, and gp91phox was elevated (51, 184, and 132%, respectively) in the clipped kidney of 2K-1C group. VitC downregulated AT(1)R in the clipped kidney (31%). Catalase (CAT) expression was reduced in clipped (70%) and nonclipped (83%) kidneys of 2K-1C rats. VitC treatment augmented the expression of glutathione peroxidase (GPx) in both clipped (185%) and nonclipped (212%) kidneys of the 2K-1C group.CONCLUSIONSThe present study suggests a role for oxidative stress in the cardiovascular and sympathetic alterations in renovascular hypertension, associated with changes in the expression of AT,R, NAD(P)H oxidase subunits, and antioxidant enzymes in the kidney. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, São Paulo, Brazil | |
| dc.description.affiliation | Universidade Federal de São Paulo Baixada Santista, Dept Biosci, São Paulo, Brazil | |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo Baixada Santista, Dept Biosci, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description.sponsorshipID | FAPESP: 04/15969-8 | |
| dc.description.sponsorshipID | FAPESP: 06/59047-2 | |
| dc.description.sponsorshipID | FAPESP: 07/56925-1 | |
| dc.format.extent | 473-480 | |
| dc.identifier | http://dx.doi.org/10.1038/ajh.2010.11 | |
| dc.identifier.citation | American Journal of Hypertension. New York: Nature Publishing Group, v. 23, n. 5, p. 473-480, 2010. | |
| dc.identifier.doi | 10.1038/ajh.2010.11 | |
| dc.identifier.issn | 0895-7061 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/32525 | |
| dc.identifier.wos | WOS:000277162600010 | |
| dc.language.iso | eng | |
| dc.publisher | Nature Publishing Group | |
| dc.relation.ispartof | American Journal of Hypertension | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.subject | baroreceptor reflex | en |
| dc.subject | blood pressure | en |
| dc.subject | hypertension | en |
| dc.subject | oxidative stress | en |
| dc.subject | renovascular | en |
| dc.subject | sympathetic nerve activity | en |
| dc.subject | vitamins | en |
| dc.title | Chronic Antioxidant Treatment Improves Arterial Renovascular Hypertension and Oxidative Stress Markers in the Kidney in Wistar Rats | en |
| dc.type | info:eu-repo/semantics/article |