Genotoxicity of corrosion eluates obtained from endosseous implants

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorMatsumoto, Mariza Akemi
dc.contributor.authorMarques Padovan, Luis Eduardo
dc.contributor.authorMarques, Mariangela Esther Alencar
dc.contributor.authorSalvadori, Daisy Maria Favero
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Sagrado Coracao
dc.contributor.institutionUniv Estadual Paulista
dc.date.accessioned2016-01-24T12:41:58Z
dc.date.available2016-01-24T12:41:58Z
dc.date.issued2007-03-01
dc.description.abstractPurpose: Commercially pure titanium alloys are currently used as metallic biomaterials in implantology. Corrosion phenomena appear to play a decisive role in metallic implant long-term behavior. Thus, the goal of this study was to examine the genotoxic potential of corrosion eluates obtained from dental implants using Chinese ovary hamster cells in vitro by the single-cell gel (comet) assay. This technique detects deoxyribonucleic acid strand breaks in individual cells in alkaline conditions.Materials and Methods: the materials tested included 3 dental implants commercially available. Each of the tested materials was corroded in a solution consisting of equal amounts of acetic acid and sodium chloride (0.1 M) for 1, 3, 7, 14, and 21 days. the Chinese ovary hamster cultures were then exposed to all corrosion eluates obtained from endosseous dental implants for 30 minutes at 37 degrees C.Results: None of the eluates was found to exhibit genotoxicity, regardless of the type of dental implant used.Conclusion: the results suggest that all dental implants tested in this study did not induce deoxyribonucleic acid breakage as depicted by the single-cell gel (comet) assay.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniv Sagrado Coracao, Dept Oral Surg, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent101-109
dc.identifierhttps://dx.doi.org/10.1097/ID.0b013e3180327663
dc.identifier.citationImplant Dentistry. Philadelphia: Lippincott Williams & Wilkins, v. 16, n. 1, p. 101-109, 2007.
dc.identifier.doi10.1097/ID.0b013e3180327663
dc.identifier.issn1056-6163
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29579
dc.identifier.wosWOS:000249965300013
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofImplant Dentistry
dc.rightsAcesso restrito
dc.subjectComet assayen
dc.subjectChinese ovary hamsteren
dc.subjectTitaniumen
dc.subjectEndosseous implantsen
dc.titleGenotoxicity of corrosion eluates obtained from endosseous implantsen
dc.typeArtigo
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