Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

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dc.citation.issue1
dc.citation.volume27
dc.contributor.authorRodrigues-Tartari, Raissa [UNIFESP]
dc.contributor.authorSwardfager, Walter
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorRohde, Luis A.
dc.contributor.authorCogo-Moreira, Hugo [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-08T13:09:29Z
dc.date.available2020-07-08T13:09:29Z
dc.date.issued2018
dc.description.abstractTo test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled Methylphenidate for children and adolescents with attention deficit hyperactivity disorder. A unidimensional model resulted in excellent adequacy indices, but only 2 indicators had very high factor loadings and low measurement errors. In terms of content, the 7 indicators showed poor reliability (=0.642)en
dc.description.abstracthowever, the set of indicators was precise in evaluating studies with a high amount of bias risk. The Cochrane model of risk of bias as it is, exhibited good fit indices but the majority of the items were not reliable to adequately capture risk of bias in the context of clinical trials of methylphenidate for ADHD.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570,First Floor, BR-04038000 Sao Paulo, Brazil
dc.description.affiliationSunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
dc.description.affiliationToronto Rehabil Inst, Univ Hlth Network, Toronto, ON, Canada
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570,First Floor, BR-04038000 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2016/08208-8
dc.format.extent-
dc.identifierhttp://doi.org/10.1002/mpr.1586
dc.identifier.citationInternational Journal Of Methods In Psychiatric Research. Hoboken, v. 27, n. 1, p. -, 2018.
dc.identifier.doi10.1002/mpr.1586
dc.identifier.issn1049-8931
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54047
dc.identifier.wosWOS:000426505900009
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofInternational Journal Of Methods In Psychiatric Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectADHDen
dc.subjectconfirmatory factor analysisen
dc.subjectmeta-analysisen
dc.subjectmethylphenidateen
dc.subjectrisk of biasen
dc.titleAssessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)en
dc.typeinfo:eu-repo/semantics/article
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