Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states

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dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorSilva, Patricia Leao da [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorCorrea, Fabiola Alvise [UNIFESP]
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorErnandes, Regina H.
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionPosgrad Program Nutr
dc.contributor.institutionDept Physiol
dc.contributor.institutionAssoc Found Incent Res
dc.contributor.institutionDept Psychobiol
dc.contributor.institutionDept Biosci
dc.contributor.institutionPosgrad Program Interdisciplinary Hlth Sci
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:48Z
dc.date.available2016-01-24T14:17:48Z
dc.date.issued2012-01-18
dc.description.abstractObjective: the purpose of the present investigation was to compare the effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms.Methods: A total of 83 obese adolescents (28 with and 55 without eating disorder symptoms) were enrolled for 1 year of interdisciplinary weight-loss therapy (clinical, nutritional, exercise, physiotherapy and psychological). Bulimic and binge eating symptoms were measured by the Bulimic Investigatory Test, Edinburgh. and the Binge Eating Scale, respectively. Leptin and adiponectin concentrations were measured with enzyme-linked immunosorbent assay kits. Visceral and subcutaneous fat were assessed by ultrasonography.Results: Both groups demonstrated improved body mass, body mass index, body fat (%), lean mass, visceral fat, subcutaneous fat, homeostasis model assessment insulin-resistance index (HOMA-IR), quantitative insulin sensitivity check index, total cholesterol, LDL-cholesterol, VLDL, triglycerides, adiponectin and leptin concentrations after therapy. We found a positive correlation between leptin concentrations and subcutaneous fat in the control group and a negative correlation between adiponectin concentrations and HOMA-IR and fat mass (%). the prevalence of obese adolescents with eating disorders was reduced by 89% after 1 year of interdisciplinary therapy.Conclusion: the eating disorder symptoms did not impair the metabolic state during weight loss therapy of obese adolescents. Additionally, long-term interdisciplinary therapy was effective in reducing the chances of developing several co-morbidities in both groups. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationPosgrad Program Nutr, São Paulo, Brazil
dc.description.affiliationDept Physiol, São Paulo, Brazil
dc.description.affiliationAssoc Found Incent Res, São Paulo, Brazil
dc.description.affiliationDept Psychobiol, São Paulo, Brazil
dc.description.affiliationDept Biosci, São Paulo, Brazil
dc.description.affiliationPosgrad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCEMSA
dc.description.sponsorshipUNIFESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 9814302-3
dc.description.sponsorshipIDFAPESP: 2006/00684-3
dc.description.sponsorshipIDFAPESP: 2008/53069-0
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.format.extent175-180
dc.identifierhttps://dx.doi.org/10.1016/j.physbeh.2011.08.014
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 105, n. 2, p. 175-180, 2012.
dc.identifier.doi10.1016/j.physbeh.2011.08.014
dc.identifier.issn0031-9384
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34532
dc.identifier.wosWOS:000300459800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhysiology & Behavior
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectObesityen
dc.subjectInterdisciplinary therapyen
dc.subjectLeptinen
dc.subjectAdiponectinen
dc.subjectEating disordersen
dc.titleObese adolescents with eating disorders: Analysis of metabolic and inflammatory statesen
dc.typeArtigo
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