Sleep disturbance induced by substance P in mice

Página do item simplificado
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorNascimento, Danielle da Cunha [UNIFESP]
dc.contributor.authorMachado, Ricardo Borges [UNIFESP]
dc.contributor.authorRoizenblatt, Suely [UNIFESP]
dc.contributor.authorMoldofsky, Harvey
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Sleep & Chronobiol
dc.date.accessioned2016-01-24T12:40:59Z
dc.date.available2016-01-24T12:40:59Z
dc.date.issued2006-02-28
dc.description.abstractSubstance P (SP) and neurokinins have been implicated in modulating pain and mood but little is known about their effect on sleep-wake behavior. the purpose of the present study was to examine the possible involvement of SP in sleep-wake mechanisms without activation of painful responses. Electrophysiological recordings of the sleep-wake cycle were conducted in C57BL/6J male mice that had intracerebral ventricular cannula inserted for drug administration. Initially, in order to determine the highest dose of SP that would not induce nociceptive response, 10 animals per group received administration of either SP doses or artificial cerebrospinal fluid (CSF-sham group) through the carmula and were assessed by the hot plate test. the sleep-wake cycle of two other groups of mice was recorded for 24 It before (baseline) and after receiving CSF (n= 10) or SP-1 mM (n = 11), dose that had been determined in the previous hot plate test. SP interfered with sleep, when compared to baseline and to sham group, by reducing sleep efficiency, increasing latency of sleep and the number of awakening bouts. To examine the reversal of SP effects, eight mice were administered with an NK1 receptor antagonist before SP administration. Prior administration of the NK1 antagonist prevented the disturbances in sleep. Conclusions: the results suggest that SP produces disturbances in sleep, likely mediated by the NK1 receptor. (c) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationCtr Sleep & Chronobiol, Sleep Disorders Clin, Toronto, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 01/04329-0pt
dc.description.sponsorshipIDFAPESP/CEPID: 98/14303-3pt
dc.format.extent212-218
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2005.09.008
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 167, n. 2, p. 212-218, 2006.
dc.identifier.doi10.1016/j.bbr.2005.09.008
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28752
dc.identifier.wosWOS:000235259200003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSubstance Pen
dc.subjectSleep disturbancesen
dc.subjectAntagonist NK1en
dc.subjectMiceen
dc.subjectPainful disturbanceen
dc.titleSleep disturbance induced by substance P in miceen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos