P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions

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dc.contributor.authorQueiroz, C.
dc.contributor.authorSilva, T. C.
dc.contributor.authorAlves, VAF
dc.contributor.authorVilla, L. L.
dc.contributor.authorCosta, M. C.
dc.contributor.authorTravassos, A. G.
dc.contributor.authorAraujo, J. B.
dc.contributor.authorStudart, E.
dc.contributor.authorCheto, T.
dc.contributor.authorFreitas, LAR de
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionLudwig Inst Canc Res
dc.date.accessioned2016-01-24T12:38:17Z
dc.date.available2016-01-24T12:38:17Z
dc.date.issued2006-01-01
dc.description.abstractAn immunohistochemical analysis with monoclonal antibody p16(INK4), was performed in formalin-fixed, paraffin-embedded samples of 60 cases. the aim was to investigate in biopsies the expression of p16(INK4a) of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16(INK4a) positive cells, reaction intensity, and cell staining pattern. All of these parameters were statistically different when compared among different histological groups. However, logistic regression model showed that the reaction intensity was the best indicator of the expression of p16(INK4a). This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients with CIN grade 1 (CIN1) expressed p16(INK4a) (all these cases were infected with high risk HPV). Our study supports the hypothesis that p16(INK4a) expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed cells. of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16(INK4a) seems to be capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression to high-grade lesions. (c) 2005 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv Fed Bahia, Sch Med, Dept Gynecol & Obstet, BR-40210 Salvador, BA, Brazil
dc.description.affiliationUniv Fed Bahia, Sch Med, Dept Pathol, BR-40210 Salvador, BA, Brazil
dc.description.affiliationFiocruz MS, Oswaldo Cruz Fdn, Goncalo Moniz Res Ctr, Salvador, BA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Adolfo Lutz Inst, Dept Pathol, São Paulo, Brazil
dc.description.affiliationLudwig Inst Canc Res, Dept Virol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Adolfo Lutz Inst, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent77-83
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2005.08.012
dc.identifier.citationPathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 202, n. 2, p. 77-83, 2006.
dc.identifier.doi10.1016/j.prp.2005.08.012
dc.identifier.issn0344-0338
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28652
dc.identifier.wosWOS:000235606000003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPathology Research and Practice
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcervical neoplasiaen
dc.subjectdiagnostic markeren
dc.subjectp16(INK4a)en
dc.subjecthuman papillomavirusen
dc.subjecthuman immunodeficiency virusen
dc.titleP16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesionsen
dc.typeinfo:eu-repo/semantics/article
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